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- Table of Contents
MAEA Antibodies
AND MAEA ELISA kits, MAEA Proteins
Many biological assays use antibodies to detect MAEA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAEA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAEA antibodies...
Designing an IHC experiment for MAEA? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the MAEA IHC GuideMAEA Infographic by Boster Bio
All MAEA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A08766-2
100 µg/vial
Cat # A08766-2
100 µg/vial
Human, Mouse, Rat
ELISA
$480
Cat # EKC1860
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1860
1 kit, containing one 96-well plate and all necessary reagents
MAEA Overview
Facts about E3 ubiquitin-protein transferase MAEA.
E3 ubiquitin-protein transferase MAEA (MAEA)
Plays a role in erythroblast enucleation and in the creation of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis.
Participates in erythroblastic island creation, that is the practical unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages.
Gene Information
| Human | |
|---|---|
| Gene Name: | MAEA |
| Uniprot: | Q7L5Y9 |
| Entrez: | 10296 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EMLP; EMP; EMPCell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; HLC-10; Human lung cancer oncogene 10 protein; lung cancer-related protein 10; macrophage erythroblast attacher; MAEA; PIG5; proliferation-inducing gene 5
Molecular Weight
Mass (kDA):
45.287 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 4p16.3 |
| Sequence: | 4; NC_000004.12 (1289890..1340148) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Cytoplasm. Nucleus, nucleoplasm. Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Detected in a nuclear, speckled-like pattern (PubMed:16510120). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity).
Diseases
- Anxiety Disorders
- Personality Disorders
- Inflammatory Bowel Diseases
- Diabetes Mellitus
- Intestinal Diseases
- Diabetes Mellitus, Non-insulin-dependent
- Paranoid Personality Disorder
- Obesity
- Depressive Disorder
- Antisocial Personality Disorder
Pathways
- Secretion
- Enucleation
- Vasodilation
- Cell Proliferation
- Cell Development
- Insulin Secretion
- Mitosis
- Immune Response
- Dna Repair
- Gluconeogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAEA
bosterbio.com/bosterbio-gene-info-cards/MAEA
References
PMID: 9763581 by Hanspal M., et al. Molecular identification and functional characterization of a novel protein that mediates the attachment of erythroblasts to macrophages.
PMID: 16510120 by Bala S., et al. Emp is a component of the nuclear matrix of mammalian cells and undergoes dynamic rearrangements during cell division.