MAP2K3 Antibodies

Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Dual specificity kinase. Is triggered by cytokines and environmental stress in vivo.

Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.

Gene Information

Human
Gene Name:	MAP2K3
Uniprot:	P46734
Entrez:	5606

Family

Belongs to:
protein kinase superfamily

Alternative Names

MAP kinase kinase 3; MAP2K3; MAPK/ERK kinase 3; MAPKK 3; MAPKK3PRKMK3dual specificity mitogen-activated protein kinase kinase 3; MEK3; MEK3MEK 3; mitogen activated protein kinase kinase 3; mitogen-activated protein kinase kinase 3; MKK3; MKK3EC 2.7.12.2; PRKMK3

Molecular Weight

Mass (kDA):
39.318 kDA

Genomic Context

Human
Location:	17p11.2
Sequence:	17; NC_000017.11 (21284679..21315240)

Tissue Specificity

Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.

Diseases

• Malignant Neoplasms
• Neoplasms
• Inflammation
• Carcinoma
• Tissue Adhesions
• Cell Transformation, Neoplastic
• Hypertrophy
• Fibrosis
• Anthrax Disease
• Arthritis
• Cell Invasion
• Malignant Neoplasm Of Breast

• Ischemia
• Physiological Stress
• Hypoxia
• Tumor Angiogenesis
• Inflammatory Response
• Rheumatoid Arthritis
• Infarction

Interacting Proteins

• DYRK1B
• LRRK2
• MAP3K5
• MAPK14
• TINF2

Pathways

• Cell Death
• Cell Cycle
• Localization
• Cell Proliferation
• Cell Growth
• Secretion
• Immune Response
• Cytokine Production
• Pathogenesis
• Transport
• Inflammatory Response
• Angiogenesis

• Nuclear Export
• Programmed Cell Death
• Keratinocyte Differentiation
• Cell Cycle Arrest
• Sensitization
• Innate Immune Response
• Glucose Transport

PTMs

• Phosphorylation
• Cleavage
• Dephosphorylation
• Reduction

• Methylation
• Oxidation
• Ribosylation
• Myristoylation

Research Areas

• Angiogenesis
• Cancer
• Hypoxia
• Lipid and Metabolism
• Phospho-Specific

• Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP2K3

Best Uses of the MAP2K3 Marker

This article will focus specifically on the MAP2K3 marker. It will cover its Targets, Applications, and Products. Boster Bio's MAP2K3 marker will also be covered. Continue reading to find out more! Below are the Best uses of the MAP2K3 marker. This protein is also used in the manufacturing of pharmaceuticals.

MAP2K3 Marker

The MAP2K3 gene is expressed in many tissues and cells and plays an important role in determining which organs develop. It regulates several genes, including Sry and MAP2K3. This marker is best used for studying cancer, diabetes and immune function. The MAP2K3 genetic variant is a key player in regulating ER and inflammation. For more information, read on.

Targets

MAP2K3 phosphorylates threonine & tyrosine in mRNAs. These are necessary for the expression inflammatory cytokines. MAP3K7 and MEK4 activate the MAP2K3 marker. MAPK14 also activates it. It activates p38MAPK kinases, MAPK8 and JNK1. It binds the TPA Response Element (or TRE), which drives the expression many cytokines.

MAP2K3 is enriched in microglia in mouse cortex, and it may contribute to SuperAging by regulating the brain immune system. MAP2K3 has been linked to microglia because of its association with AD. It is also upregulated in the middle temporal gyrus of AD patients. Additionally, MAP2K3 expression in AD patients' cortex, including the hippocampus, has been shown to be increased.

The MAP2K2A/MAP2K3 proteins interact with the p38 protein family. This protein acts as a scaffold for MAP3K1 and MAP2K2K, (MEK4). These proteins are a signaling pathway as well as a molecular recognition systems. In addition, MAP2K1 is a target of p38ab isoforms.

The MAP2K3 target miR-690 in mice was shown to repress luciferase activity. In the same way, constant expressions of miR-690 could reduce the activity of luciferase reporters in 3T3L1 cell by as much as 50%. NC and Mimic altered the 3'UTR in order to block miRNA binding. Luciferase activity was rediscovered in the 3'UTR mutated group.

Invitrogen has a test that can be used to assess the expression of the MAP2K3 genes in human cells. This service uses the LanthaScreen eu kinase binding test and Z'-LYTE kinase testing assay. The service is available from Invitrogen in Madison, WI. TAK-931 also induces DNA RS (and DDR), DNA synthesis, and S2-G2 phase arrest. It also induces pCDC2, and gH2A.X expressions.

Applications

The current disclosure focuses primarily upon the MAP2K3 Biomarker and other Biomarkers as noted in Table 1. These biomarkers may be further divided into functional group according to their function. These biomarkers can be classified into functional groups based on their functions. They include those involved DNA replication, signal transduction (transcription factor activity), ribosome biogenesis, cell proliferation and signal transduction. Functional classifications also allow for the classification of additional genes. The MAP2K3 biomarker could have many applications in medical diagnostics or drug development.

The invention also contains biomarkers that detect levels of MAP2K3 within tumor cells. These biomarkers are useful in determining the best subjects for treatment, monitoring disease progression, and assessing their response to treatments. These biomarkers can be particularly useful in this aspect.

Products

The 17q11.2 location of the MAP2K3 gene contains a protein kinase. Its function, however, is unknown. It is necessary for proper functioning in many tissues. This gene is closely related with other MAP2K markers. Some of these markers can be found at the same spot. If you're interested in learning more about these proteins, please read our complete MAP2K3 guide.

The brain's nucleus houses the MAP2K3 protein. It is a subunit within the MAP-family. It is involved with the processing of fatty acid and the formation cholesterol. It plays a key role in cholesterol metabolism as well as the synthesis and maintenance of phospholipids. The MAP2K3 Gene is found in the brain, lungs, skin, and kidneys.

MAP2K3 Signaling is responsible to the diverse biological functions that the MAP2K3 Gene performs. MAP2K3 is also associated with the activation of p38 MAPK. Interestingly, when cardiac fibroblasts cocultured with TGCre or ATF3fl/fl mice, p38 phosphorylation was increased. These results suggest ATF3 may inhibit hypertensive remodeling, by suppressing Map2K3 gene expression.

MAP2K3 and NCOR1 were chosen as master genes. They possess homozygous regions which were associated with disease severity. CHD is caused in part by the defective variants of these genes. This gene also acts like a transcription factor. A defective MAP2K3 gene could indicate a heart condition. Analyzing its coding area can provide a complete report.