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- Table of Contents
MAPK15 Antibodies
AND MAPK15 ELISA kits, MAPK15 Proteins
Many biological assays use antibodies to detect MAPK15, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MAPK15 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MAPK15 antibodies...
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MAPK15 Infographic by Boster Bio
All MAPK15 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA
$480
Cat # EKC1201
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1201
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse
ELISA
$540
Cat # EKC2257
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2257
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA, IF, IHC, WB
$380
Cat # A10088T175Y177
100ul
Cat # A10088T175Y177
100ul
MAPK15 Overview
Facts about Mitogen-activated protein kinase 15.
Mitogen-activated protein kinase 15 (MAPK15)
Atypical MAPK protein which regulates several process like autophagy, ciliogenesis, protein trafficking/secretion and genome integrity, in a kinase activity-dependent way (PubMed:22948227, PubMed:24618899, PubMed:29021280, PubMed:21847093, PubMed:20733054). Controls both, basal and starvation-induced autophagy throught its interaction with GABARAP, MAP1LC3B and GABARAPL1 resulting in autophagosome formation, SQSTM1 degradation and reduced MAP1LC3B inhibitory phosphorylation (PubMed:22948227).
Regulates primary cilium formation and the localization of ciliary proteins involved in cilium structure, transport, and signaling (PubMed:29021280). Prevents the movement of the sugar-adding enzymes from the Golgi to the endoplasmic reticulum, thereby restricting the production of sugar-coated proteins (PubMed:24618899).
Gene Information
| Human | |
|---|---|
| Gene Name: | MAPK15 |
| Uniprot: | Q8TD08 |
| Entrez: | 225689 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; ERK-7; ERK7MAPK 15; ERK-8; ERK8EC 2.7.11.24; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; mitogen-activated protein kinase 15
Molecular Weight
Mass (kDA):
59.832 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q24.3 |
| Sequence: | 8; NC_000008.11 (143716305..143722458) |
Tissue Specificity
Widely expressed with a maximal expression in lung and kidney.
Subcellular Localizations
Cytoplasm, cytoskeleton, cilium basal body. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasmic vesicle, autophagosome. Golgi apparatus. Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Co-localizes to the cytoplasm only in presence of ESRRA (PubMed:21190936). Translocates to the nucleus upon activation (PubMed:20638370). At prometaphase I, metaphase I (MI), anaphase I, telophase I, and metaphase II (MII) stages, is stably detected at the spindle (By similarity).
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Hyperplasia
Interacting Proteins
- CDK2
Pathways
- Localization
- Cell Proliferation
- Macroautophagy
- Cellular Localization
- Catabolic Process
- Autophagy
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAPK15
bosterbio.com/bosterbio-gene-info-cards/MAPK15
References
PMID: 11875070 by Abe M.K., et al. ERK8, a new member of the mitogen-activated protein kinase family.
PMID: 16484222 by Iavarone C., et al. Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene.