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- Table of Contents
MBD4 Antibodies
AND MBD4 ELISA kits, MBD4 Proteins
Many biological assays use antibodies to detect MBD4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MBD4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MBD4 antibodies...
Designing a Western blot for MBD4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MBD4 Western Blot GuideMBD4 Infographic by Boster Bio
All MBD4 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03476-2
100 μg/vial
Cat # A03476-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03469-1
100 μg/vial
Cat # A03469-1
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03462
100 μg/vial
Cat # A03462
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A03464-2
100 μg/vial
Cat # A03464-2
100 μg/vial
MBD4 Overview
Facts about Methyl-CpG-binding domain protein 4.
Methyl-CpG-binding domain protein 4 (MBD4)
Mismatch-specific DNA N-glycosylase involved in DNA repair.
Has thymine glycosylase activity and is unique for G:T mismatches within methylated and unmethylated CpG websites.Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | MBD4 |
| Uniprot: | O95243 |
| Entrez: | 8930 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EC 3.2.2.-; G/T mismatch glycosylase; G/U mismatch glycosylase; MBD4; MED1G/5-fluorouracil mismatch glycosylase with biphasic kinetics; methyl-CpG binding domain protein 4; methyl-CpG-binding domain protein 43,N(4)-ethenocytosine glycosylase; Methyl-CpG-binding endonuclease 1; Methyl-CpG-binding protein MBD4; Mismatch-specific DNA N-glycosylase; putative methyl-CpG binding protein
Molecular Weight
Mass (kDA):
66.051 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q21.3 |
| Sequence: | 3; NC_000003.12 (129430944..129440179, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Metabolic Bone Disorder
- Microsatellite Instability
- Colorectal Cancer
- Cell Transformation, Neoplastic
- Carcinoma
- Colorectal Neoplasms
- Mutation, Out-of-frame
- Carcinogenesis
- Malignant Tumor Of Colon
- Rett Syndrome
- Malignant Neoplasm Of Lung
Interacting Proteins
- FADD
- MLH1
Pathways
- Methylation
- Mismatch Repair
- Dna Methylation
- Dna Repair
- Demethylation
- Dna Demethylation
- Pathogenesis
- Cell Cycle
- Dna Replication
- Gene Silencing
- Dna Hypomethylation
- Chromatin Remodeling
- Localization
PTMs
- Methylation
- Deamination
- Demethylation
- Acetylation
Research Areas
- Base Excision Repair
- Chromatin Research
- DNA Repair
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MBD4
bosterbio.com/bosterbio-gene-info-cards/MBD4
References
PMID: 9774669 by Hendrich B., et al. Identification and characterization of a family of mammalian methyl- CpG binding proteins.
PMID: 10441743 by Hendrich B., et al. Genomic structure and chromosomal mapping of the murine and human mbd1, mbd2, mbd3, and mbd4 genes.