MC2R Antibodies

AND MC2R ELISA kits, MC2R Proteins

Many biological assays use antibodies to detect MC2R, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MC2R in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MC2R antibodies...

We validate the specificity of these antibodies to MC2R by testing them on tissues known to express MC2R positively and negatively. Browse below to find the MC2R antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for MC2R? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the MC2R Western Blot Guide

MC2R Infographic by Boster Bio

All MC2R Products

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Product

Figures

Specificity

Applications

Price

Anti-MC2 receptor/MC2R Antibody Picoband®

Western blot analysis of MC2R using anti-MC2R antibody (A02306-1)

Flow Cytometry analysis of U251 cells using anti-MC2R antibody (A02306-1)

Human, Mouse, Rat

Flow Cytometry, WB

$370
Cat # A02306-1
100 μg/vial

MC2 receptor (MC2R) (NM_000529) Human Over-expression Lysate

Human

$628
Cat # LS004158
20 µg, 100 µg

MC2 receptor (MC2R) (NM_000529) Human Recombinant Protein

Coomassie blue staining of purified MC2R protein

$1062
Cat # PROTQ01718
20 µg

MC2R Overview

Facts about Adrenocorticotropic hormone receptor.

MC2R 3D structure. Source: alphafold

Adrenocorticotropic hormone receptor (MC2R)

Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP).

Gene Information

Human
Gene Name:	MC2R
Uniprot:	Q01718
Entrez:	4158

Family

Belongs to:

G-protein coupled receptor 1 family

Alternative Names

ACTH receptor; ACTHR; ACTH-R; ACTHRcorticotropin receptor; adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; MC2 receptor; MC2R; MC2-R; melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin receptor 2; Melanocortin-2 R; Melanocortin2R; Melanocortin-2R; MGC125798

Molecular Weight

Mass (kDA):
33.927 kDA

Genomic Context


Human

Location:	18p11.21
Sequence:	18; NC_000018.10 (13882042..13915707, complement)

Tissue Specificity

Melanocytes and corticoadrenal tissue.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Pituitary Diseases
Adrenal Gland Hypofunction
Neoplasms
Adrenal Gland Diseases
Tumors Of Adrenal Cortex
Hyperpigmentation
Hypoglycemia
Physiological Stress
Hyperplasia
Glucocorticoid Deficiency With Achalasia
Hypoplasia

Addison Disease
Obesity
Adrenal Hyperplasia
Adrenal Gland Neoplasms
Cushing Syndrome
Adenoma

Interacting Proteins

MRAP
MRAP2

Pathways

Secretion
Localization
Cortisol Secretion
Pigmentation
Response To Stress
Gland Development
Energy Homeostasis
Mineralocorticoid Secretion
Adrenal Gland Development
Inflammatory Response
Ovulation
Regeneration
Receptor Internalization

Transport
Sensitization
Translation
Angiogenesis
Clathrin-mediated Endocytosis
Osteoblast Differentiation
Catecholamine Secretion

PTMs

Cleavage
Phosphorylation

Glycosylation
Acetylation

Ubiquitination

Research Areas

GPCR

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MC2R

References

PMID: 1325670 by Mountjoy K.G., et al. The cloning of a family of genes that encode the melanocortin receptors.

PMID: 8463333 by Gantz I., et al. Molecular cloning of a novel melanocortin receptor.