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- Table of Contents
Facts about Adrenocorticotropic hormone receptor.
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Human | |
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Gene Name: | MC2R |
Uniprot: | Q01718 |
Entrez: | 4158 |
Belongs to: |
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G-protein coupled receptor 1 family |
ACTH receptor; ACTHR; ACTH-R; ACTHRcorticotropin receptor; adrenocorticotropic hormone receptor; Adrenocorticotropin receptor; MC2 receptor; MC2R; MC2-R; melanocortin 2 receptor (adrenocorticotropic hormone); Melanocortin receptor 2; Melanocortin-2 R; Melanocortin2R; Melanocortin-2R; MGC125798
Mass (kDA):
33.927 kDA
Human | |
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Location: | 18p11.21 |
Sequence: | 18; NC_000018.10 (13882042..13915707, complement) |
Melanocytes and corticoadrenal tissue.
Cell membrane; Multi-pass membrane protein.
One of the most important genetic markers in the human body is the G protein-coupled receptor. The MC2R is a member of the family of melanocortin receptors. It is an important member in the family of receptors that recognize different hormones, such as insulin. Continue reading to learn more about MC2R. These are some of the many uses that this marker can be used in.
Whether you are doing a WB application or a special species study, the MC2R marker is one of the most effective tools to test the mRNA of the MC2R protein. Several Boster antibodies have been validated for use in ELISA, Western Blotting, and Immunohistochemistry. They have been rigorously tested to ensure their accuracy and sensitivity.
The MC2R marker belongs to the G protein-coupled receptor family. It recognizes melanocortin ligands. It is located on 18p11.2 and activated selectively with adrenocorticotropichormone (ACTH). The MC2R recognizes a variety of melanocortin ligands. People with this gene mutation are at risk for familial glucocorticoid deficiency, which results in a high plasma ACTH level.
MC2R is a receptor found in the kidney. It regulates actin cytoskeleton signaling. It inhibits EGFR, thereby restoring podocyte's stress fibers. This receptor has been shown by podocytes to protect them against protamine sulfate-induced loss of stress fibers. The MC2R not only has positive effects but also restores podocyte function through stabilizing synaptopodin, RhoA stress fiber formation, and other benefits.
Patients with MN show increased expression of the MC1R-expressing renal cells. A colocalization analysis with synaptopodin demonstrated that MC1R-expression was higher in MN patients and those with renal glomerular disease. This marker can be used in clinical trials to identify the presence of this protein. The MC1R tagged mRNA can be used in many ways. Its utility is increasing and it can help researchers improve diagnosis in renal nephropathy.
The MC1R/MC2R gene complex is a very specific gene that is expressed throughout many organs including the heart. It is found in specific types of kidney cells and endothelial tissues, as well as the cortex of human kidneys. The MC1R-induced Src activation by EGFR-669 has been inhibited and stabilized by synaptopodin-induced stress fibre formation.
The regulation PS in rat earcells can be regulated by the MC1R/MC2R receptor. The stabilization actin stress fibers can be achieved by activating the MC1R/MC2R combination. Activation by the MC1R-MC2R complex can be used to identify PS. Most MC1R mutations impair the ERK1/2 pathway and inhibit the MC1R-MC2R signaling.
MC2R (ligand-dependent G proteins-coupled receptor) is found in your adrenal gland. It activates adenylylcyclase, which produces cAMP. The cAMP activates the protein kinase. Numerous studies have investigated the mechanism by which ACTH stimulates your adrenal gland. It is not clear how ACTH stimulates the adrenal gland. It is difficult to determine if MC2R is linked to specific functional expression in systems that have endogenous MSCR.
MRAP is a novel protein that is required for the transport of MC2R from the cell surface. It may also play a part in binding ACTH-ligands to the MC2R. MRAP is expressed rapidly, whereas the MC2R responds much more slowly. Recent studies show that the half-life time of MRAP proteins is short.
In this study, the expression of MC2R-GFP was determined in 293/FRT cells. MC2RGFP-transfected cells had significantly different maximal responses and EC50 values than untransfected control cell lines. MC2RGFP was also expressed at nuclear planes of the cells. To determine the level of MC2R–GFP expression, cell adhesion was measured on the coverslip.
The plasma membrane expresses the MC2R at high levels, but the MRAP ioforms have distinct functional properties. MRAPb has lower affinity ACTH binding than MRAPa. Cells expressing MRAPa have a higher cAMP response and are more responsive to ACTH stimulation. Further, MRAPb hasoforms were also found near MC2R cell surface.
The MC2R receptor is a G-protein coupled receptor. It regulates cell metabolism and the production cAMP. ACTH and other G-protein-coupled hormones are essential for the immune system. The MC2R mediates this response by mediating the activity G-protein-coupled receptors within the body. It is important for us to understand the role that this receptor plays in regulating these processes.
Both MRAP, and MC2R could be relatively labile. Uncomplexed MC2R may not respond to ACTH stimulation. MRAP-independent MC2R could exist at the cell surface. Additionally, a newly transcribed MRAP mRNA may facilitate the recruitment a functional MC2R onto the cell surface. This could increase the cellular response's speed and efficiency.
It is a melanocortinoid ligand. It regulates melanocortin-2R expression in a variety ocells. Signaling controls its role in cell-surface trafficking. Recent research suggests MRAP may play a critical role in MCR regulation. Recent studies have identified MRAP, a potential accessory factor to MC2R, and a role for the trafficking of MC2R between the ER and the cell surface.
MC2R works as a GPCR (G-protein-coupled) receptor. It is the shortest-known melanocortin receptor and the smallest GPCR. Early studies have shown that the active MC2R exists in heterohexameric complexes as a dimer with the antiparallel MRAP dimer. Liang et al. suggest that MC2R-mediated ACTH binding involves two steps: first, the KKRRP segment engages the MC2R and then causes conformational changes in the HFRW-binding domain.
PMID: 1325670 by Mountjoy K.G., et al. The cloning of a family of genes that encode the melanocortin receptors.
PMID: 8463333 by Gantz I., et al. Molecular cloning of a novel melanocortin receptor.