Microspherule protein 1 Antibodies

AND MCRS1 ELISA kits, Microspherule protein 1 Proteins

Many biological assays use antibodies to detect Microspherule protein 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Microspherule protein 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Microspherule protein 1 antibodies...

We validate the specificity of these antibodies to Microspherule protein 1 by testing them on tissues known to express MCRS1 positively and negatively. Browse below to find the MCRS1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MCRS1 Infographic by Boster Bio

All MCRS1 Products

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Specificity

Applications

Price

MCRS1 (NM_006337) Human Over-expression Lysate

Human

$628
Cat # LS010445
20 µg, 100 µg

Anti-MCRS1 antibody

Human, Mouse, Rat

ELISA, WB

$370
Cat # A03868-1
100 μl/vial

MCRS1 Overview

Facts about Microspherule protein 1.

MCRS1 3D structure. Source: alphafold

Microspherule protein 1 (MCRS1)

Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852).

Putative regulatory part of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100).

Gene Information

Human
Gene Name:	MCRS1
Uniprot:	Q96EZ8
Entrez:	10445

Family

Belongs to:

No superfamily

Alternative Names

Cell cycle-regulated factor p78; ICP22BP; INO80 complex subunit Q; INO80Q58 kDa microspherule protein; MCRS2INO80 complex subunit J; microspherule protein 1; MSP58cell cycle-regulated factor (78 kDa); P78

Molecular Weight

Mass (kDA):
51.803 kDA

Genomic Context


Human

Location:	12q13.12
Sequence:	12; NC_000012.12 (49558294..49568233, complement)

Tissue Specificity

Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.

Subcellular Localizations

Nucleus. Nucleus, nucleolus. Cytoplasm. In microspherules in the nucleolus.

Diseases

Neoplasms
Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Cell Transformation, Neoplastic
Metaplastic Cell Transformation
Multiple Organ Failure
Liver Carcinoma
Liver Neoplasms
Neoplasm Metastasis
Esophageal Diseases
Metastatic Malignant Neoplasm To The Liver
Glioma

Aneuploidy
Neoplasm Invasiveness
Carcinogenesis
Carcinoma
Cholecystitis
Fibrosarcoma

Interacting Proteins

BRMS1L
CCDC13
CDCA7L
CEP44
DAXX

FXR2
GPBP1
HMBOX1
IKZF1
INO80E

KIAA1958
KXD1
MAP3K5
MED4
NKAPD1

PHC2
TRIM37
USHBP1
WASHC3
WBP11

ZBTB22

Pathways

Cell Cycle
Cell Proliferation
Localization
S Phase
Chromosome Segregation
Cell Cycle Arrest
Translation
Spindle Assembly
Transport
Cellular Senescence
Mitosis
G1 Phase
Regulation Of Gene Expression

Intracellular Signal Transduction
Dosage Compensation
Senescence
Replicative Senescence
Cell Division
Cell Death
Telomere Maintenance

PTMs

Phosphorylation

Acetylation

Ubiquitination

Research Areas

Cell Cycle and Replication

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MCRS1

References

PMID: 9654073 by Ren Y., et al. The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120.

PMID: 9765390 by Bruni R., et al. Herpes simplex virus 1 regulatory protein ICP22 interacts with a new cell cycle-regulated factor and accumulates in a cell cycle-dependent fashion in infected cells.