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- Table of Contents
Facts about Histone-lysine N-methyltransferase MECOM.
May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Human | |
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Gene Name: | MECOM |
Uniprot: | Q03112 |
Entrez: | 2122 |
Belongs to: |
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No superfamily |
AML1-EVI-1 fusion protein; AML1-EVI-1; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI1; EVI-1; EVI1MDS1-EVI1; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1 and EVI1 complex locus; MDS1; MECOM; MGC163392; MGC97004; Myelodysplasia syndrome 1 protein; myelodysplasia syndrome 1; Myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1
Mass (kDA):
138.136 kDA
Human | |
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Location: | 3q26.2 |
Sequence: | 3; NC_000003.12 (169083499..169663781, complement) |
Nucleus. Nucleus speckle. Cytoplasm.
If you're unfamiliar with MECOM Marker, you've come to the right place. This protein regulates cell proliferation and differentiation. Learn more about the many benefits of MECOM Marker in the body. Also, discover how to find it in your own cells. The information below will help you learn more about this important protein. Listed below are some of its best uses. And don't miss out on future posts about MECOM Marker!
Among the many proteins involved in cell proliferation and differentiation, the MECOM Marker belongs to the positive regulatory domain family and is expressed as multiple alternatively spliced variants. The original MECOM protein is encoded by the MDS1 gene and MECOM (E) is expressed by splicing the EVI1 gene with MDS1 exon 2. This protein contains a zinc finger motif and functions as a transcription factor. The protein contributes to acute leukemia.
The expression of MECOM is reduced when cells are exposed to IM. A recent study found that single cells treated with IM showed a significant decrease in the expression of MECOM (E) and MECOM (M). In addition, MECOM gene transcripts were more highly expressed in CML-CP cells than in NT cells, which suggests that a role for MECOM in the cell cycle has been identified.
The gene encoding EVI1 encodes a 145 kDa protein. It has seven zinc finger domains on the N-terminal and three finger motifs on the C-terminal region. A proline-rich region is located in the middle. In mice, a splice variant lacking zinc fingers 6 and 7 is called PRDM3/EVI1/D324 and is present in the repression domain.
PRDM9 is a class II arginine methyltransferase that binds sequence motifs on DNA. The PRDM9 gene is derived from the mRNA of the upstream gene and the EVI1 exon 2 in the corresponding mRNA. The resulting protein, MDS1/EVI1, contains a PR domain, which is derived from the EVI1 protein.
This study was supported by the National Natural Science Foundation of China. The study was conducted by using biochemical techniques to detect the presence of MECOM Marker in human breast cells. To measure the protein concentration, cells were monitored every day for 4 days and classified as either proliferating or differentiated. In this way, MECOM Marker has the potential to be a valuable tool for understanding the regulation of cell proliferation and differentiation.
While the role of PRDM5 in regulating hematopoiesis is not clear, this protein is thought to interact with the Growth factor independent 1 (Gfi1) transcription factor. Inactivation of Gfi1 causes neutropenia and lymphopenia. Moreover, PRDM5 functions as a sequence-specific DNA binding transcription factor, recruiting histone deacetylases to target genes promoters.
The PRDM2 gene controls the bidirectional cell fate switch between skeletal myoblasts and brown adipose cells. This transcription factor also interacts with the MEF2 transcription factor family. Both proteins are believed to drive the development of multiple cell types. The MEF2 transcription factors control cell differentiation, migration, apoptosis, and cell shape.
PMID: 2115646 by Morishita K., et al. Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.
PMID: 8643684 by Fears S., et al. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.