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- Table of Contents
MECOM Antibodies
AND MECOM ELISA kits, MECOM Proteins
Many biological assays use antibodies to detect MECOM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MECOM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MECOM antibodies...
Designing a Western blot for MECOM? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the MECOM Western Blot GuideMECOM Infographic by Boster Bio
All MECOM Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A04590-1
100 μg/vial
Cat # A04590-1
100 μg/vial
Human
ELISA
$480
Cat # EKC1799
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1799
1 kit, containing one 96-well plate and all necessary reagents
MECOM Overview
Facts about Histone-lysine N-methyltransferase MECOM.
Histone-lysine N-methyltransferase MECOM (MECOM)
Isoform 1: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their saying. Oncogene which plays a role in development, cell proliferation and differentiation.
May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | MECOM |
| Uniprot: | Q03112 |
| Entrez: | 2122 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AML1-EVI-1 fusion protein; AML1-EVI-1; ecotropic viral integration site 1; Ecotropic virus integration site 1 protein homolog; EVI1; EVI-1; EVI1MDS1-EVI1; MDS1 and EVI1 complex locus protein EVI1; MDS1 and EVI1 complex locus protein MDS1; MDS1 and EVI1 complex locus; MDS1; MECOM; MGC163392; MGC97004; Myelodysplasia syndrome 1 protein; myelodysplasia syndrome 1; Myelodysplasia syndrome-associated protein 1; oncogene EVI1; PRDM3; zinc finger protein Evi1
Molecular Weight
Mass (kDA):
138.136 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q26.2 |
| Sequence: | 3; NC_000003.12 (169083499..169663781, complement) |
Subcellular Localizations
Nucleus. Nucleus speckle. Cytoplasm.
Diseases
- Leukemia
- Myeloid Leukemia
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia, Chronic
- Dysmyelopoietic Syndromes
- Malignant Neoplasms
- Chromosomal Translocation
- Leukemogenesis
- Cytogenetic Abnormality
- Neoplasms
- Blast Phase
- Cell Transformation, Neoplastic
Interacting Proteins
- Ctbp2
- FOS
- RBBP4
- SIRT1
- UXT
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Oncogenesis
- Methylation
- Cell Cycle
- Cell Differentiation
- Interphase
- Localization
- Cell Death
- Dna Hypermethylation
- Cell Adhesion
- Contact Inhibition
PTMs
- Methylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MECOM
bosterbio.com/bosterbio-gene-info-cards/MECOM
References
PMID: 2115646 by Morishita K., et al. Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts.
PMID: 8643684 by Fears S., et al. Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.