MMACHC Antibodies

AND MMACHC ELISA kits, MMACHC Proteins

Many biological assays use antibodies to detect MMACHC, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MMACHC in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MMACHC antibodies...

We validate the specificity of these antibodies to MMACHC by testing them on tissues known to express MMACHC positively and negatively. Browse below to find the MMACHC antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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MMACHC Infographic by Boster Bio

All MMACHC Products

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Product

Figures

Specificity

Applications

Price

Anti-MMACHC Antibody

Western blot analysis of extracts of various cell lines, using MMACHC antibody

Human, Mouse, Rat

$405
Cat # A03398
100ul

MMACHC (NM_015506) Human Recombinant Protein

$1249
Cat # PROTQ9Y4U1
20 µg

Anti-MMACHC Mouse Monoclonal Antibody [Clone ID: OTI1A4]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MMACHC (Right lane) cDNA for 48 hrs and lysed

Human

Flow Cytometry, IF, IHC, WB

$523
Cat # M03398
100 µl

MMACHC (NM_015506) Human Over-expression Lysate

Human

$628
Cat # LS025974
20 µg, 100 µg

Anti-MMACHC Antibody Picoband®

Western blot analysis of MMACHC using anti-MMACHC antibody (A03398-1)

Flow Cytometry analysis of JK cells using anti-MMACHC antibody (A03398-1)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A03398-1
100 µg/vial

MMACHC Overview

Facts about Methylmalonic aciduria and homocystinuria type C protein.

MMACHC 3D structure. Source: alphafold

Methylmalonic aciduria and homocystinuria type C protein (MMACHC)

Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate (PubMed:19700356, PubMed:21697092, PubMed:22642810). Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin (PubMed:19801555, PubMed:22642810, PubMed:25809485).

Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen (PubMed:19801555). Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and other, related vitamin B12 derivatives (PubMed:21071249).

Gene Information

Human
Gene Name:	MMACHC
Uniprot:	Q9Y4U1
Entrez:	25974

Family

Belongs to:

MMACHC family

Alternative Names

cblC; DKFZP564I122; FLJ25671; methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria; methylmalonic aciduria and homocystinuria type C protein; RP11-291L19.3

Molecular Weight

Mass (kDA):
31.728 kDA

Genomic Context


Human

Location:	1p34.1
Sequence:	1; NC_000001.11 (45500229..45513382)

Tissue Specificity

Widely expressed. Expressed at higher level in fetal liver. Also expressed in spleen, lymph node, thymus and bone marrow. Weakly or not expressed in peripheral blood leukocytes.