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- Table of Contents
Facts about Natural cytotoxicity triggering receptor 3.
It controls, for example, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Human | |
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Gene Name: | NCR3 |
Uniprot: | O14931 |
Entrez: | 259197 |
Belongs to: |
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natural cytotoxicity receptor (NCR) family |
Activating natural killer receptor p30; CD337 antigen; CD337; CD337activating NK-A1 receptor; LY117,1C7NK-p30; lymphocyte antigen 117; natural cytotoxicity triggering receptor 3; Natural killer cell p30-related protein; NCR3; NKp30; NKp30MALS
Mass (kDA):
21.593 kDA
Human | |
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Location: | 6p21.33 |
Sequence: | 6; NC_000006.12 (31588895..31593024, complement) |
Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.
Cell membrane; Single-pass type I membrane protein.
PMID: 10562324 by Pende D., et al. Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells.
PMID: 10202016 by Neville M.J., et al. A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.