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Facts about NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1.
The immediate electron acceptor for the enzyme is believed to be ubiquinone. .
Human | |
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Gene Name: | NDUFA1 |
Uniprot: | O15239 |
Entrez: | 4694 |
Belongs to: |
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complex I NDUFA1 subunit family |
CI-MWFEcomplex I MWFE subunit; Complex I-MWFE; MWFENADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1 (7.5kD, MWFE); NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa; NADH oxidoreductase subunit MWFE; NADH:ubiquinone oxidoreductase (complex 1); NADH-ubiquinone oxidoreductase MWFE subunit; type I dehydrogenase; ZNF183
Mass (kDA):
8.072 kDA
Human | |
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Location: | Xq24 |
Sequence: | X; NC_000023.11 (119871832..119876662) |
Primarily expressed in heart and skeletal muscle.
Mitochondrion inner membrane; Single-pass membrane protein; Matrix side.
You have reached the right place if your search for anti-NDUFA1 antibodies. Learn more about Boster Bio Anti-NDUFA1 markers' Specificity, Validation and Applications. In addition to the antibody's Specificity, Boster offers antibodies that are validated in Western Blotting, Immunohistochemistry, and ELISA.
Boster Bio's Anti NDUFA1 Marker has been validated against a variety platforms with positive and negative samples. The antibodies are extremely specific and possess high affinity. Boster provides product credits to scientists that have reviewed their products. Unique validation processes ensure product performance. Here are the key benefits of Boster’s Anti NDUFA1Marker.
The anti NDUFA1 antibody is tested in ICC (IHC-F), WB and on a variety ocell types and tissues. This Boster Bio product reacts with Human, Mouse, and Rat. This means that it exhibits broad anti-NDUFA1 activities. You can request a Boster Bio Anti NDUFA1Marker to be used in immunoassays. Please contact the manufacturer for more information.
To test the specificity of the NDUFA1 gene, we cloned both human and bovine cDNAs using the RACE protocol. Both mutant cell line produced cDNAs containing wild-type NDUFA1 sequence. We also cloned NDUFA1 cDNAs derived from hamster cells. They contained the same mutations found in human cells.
We cloned human complex I using the pIRESneo, pTRIDENT14 vectors in this study. We added the neoR gene to the pTRIDENT14 using the vector pIRESneo. The resulting vector was named pTRIDENT14–neo. The MWFE coding sequences were then cloned into the first cistron.
The hamster NDUFA1 cDNA did not complement the hamster mutation. Despite high sequence conservation in the human NDUFA1 and hamster NDUFA1, amino Acids 39 and 46 differ between hamsters and mice. Additionally, the spacing between positive charges in the mouse MWFE region is different. If the hamster mutant is found in the human cell line, it can be used for mutation analysis.
The present invention provides methods to detect AMLSC or AML and determine their severity, prognosis, and responsiveness for therapy. These methods can either be used with whole cells or isolated cells. These methods can be used in a variety of ways, including diagnosis, screening, therapy, and treatment. They can be used to identify patients with acute myeloidleukemia. They can also be used to monitor patient progress and diagnose them.
PMID: 8938439 by Zhuchenko O., et al. Isolation, mapping, and genomic structure of an X-linked gene for a subunit of human mitochondrial complex I.
PMID: 9224902 by Frattini A., et al. Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25.