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- Table of Contents
Facts about NSFL1 cofactor p47.
May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563).
| Human | |
|---|---|
| Gene Name: | NSFL1C |
| Uniprot: | Q9UNZ2 |
| Entrez: | 55968 |

| Belongs to: |
|---|
| NSFL1C family |

dJ776F14.1; NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; p47; p97 cofactor p47; SHP1 homolog; UBX domain protein 2C; UBX domain-containing protein 2C; UBX1; UBXD10; UBXN2CMGC3347
Mass (kDA):
40.573 kDA

| Human | |
|---|---|
| Location: | 20p13 |
| Sequence: | 20; NC_000020.11 (1442162..1467793, complement) |
Nucleus. Golgi apparatus, Golgi stack. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase.





PMID: 23649807 by Kress E., et al. The UBXN-2/p37/p47 adaptors of CDC-48/p97 regulate mitosis by limiting the centrosomal recruitment of Aurora A.
PMID: 15498563 by Soukenik M., et al. The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L.