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- Table of Contents
Facts about Nuclear pore complex protein Nup98-Nup96.
May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes (PubMed:28221134).
Human | |
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Gene Name: | NUP98 |
Uniprot: | P52948 |
Entrez: | 4928 |
Belongs to: |
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nucleoporin GLFG family |
ADAR2; ADIR2; GLFG-repeat containing nucleoporin; nuclear pore complex protein Nup98-Nup96; nucleoporin 98kD; nucleoporin 98kDa; NUP196; NUP96; Nup98-Nup96
Mass (kDA):
197.579 kDA
Human | |
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Location: | 11p15.4 |
Sequence: | 11; NC_000011.10 (3675010..3797554, complement) |
Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Localized to the nucleoplasmic side of the nuclear pore complex (NPC), at or near the nucleoplasmic basket (PubMed:11839768). Dissociates from the dissasembled NPC structure early during prophase of mitosis (PubMed:12802065). Colocalized with NUP153 and TPR to the nuclear basket of NPC (PubMed:11839768). Colocalized with DHX9 in diffuse and discrete intranuclear foci (GLFG-body) (PubMed:11839768, PubMed:28221134). Remains localized to the nuclear membrane after poliovirus (PV
In this Boster Bio article, we'll look at the NUP98 marker and how scientists can utilize it to study species, applications, and special samples. Boster scientists also can earn product credits and report their results to the scientific community. These products and services are accessible to scientists from all over the world. Read on to find more. Here are a few examples of the best uses of the NUP98 marker.
The NUP98 marker is a relevant genomic locus. The NUP98 gene has been linked with more than 500 genes in humans. The locus is highly conserved in the genome, so that it is possible to utilize it for various research applications. It has been extensively utilized in human genetic studies and is used to identify the chromosomes Z, Y.
The Boster bio Best Uses for the NUP98 marker is a highly specific antibody that is available for research. Boster antibodies are high-affinity and are validated for use in immunohistochemistry, Western Blotting, and ELISA. Researchers can submit their results for specific species or applications to earn product credits and recognition. Boster has antibodies that can be used in a variety of species and applications, including mice, humans, and fish.
Recent research showed that MEIS1 expression was greater in clones with a monoallelic HA tag gene than clones lacking the HA tag gene. These findings are in line with previous studies that showed those clones tagged with HA expressed more MEIS1 transcripts. Mono-allelic tagged Clones also expressed approximately half of the MEIS1 transcripts when compared to the clones that were parented.
NUP98 serves many purposes. The molecular biology of MEIS is the most significant function. This gene is involved in an array of biological processes and is a major regulator of platelet formation. It interacts with proteins involved in DNA methylation and protein ubiquitination. These interactions between molecular molecules are essential for cell functions and processes.
MEIS1 is implicated in a variety of pathological and physiological processes. This gene regulates cell growth by interfacing with its MEIS-interacting domain within HOXB13. MEIS1 also blocks tumor growth through promoting the expression of decorin, an inhibitor of multiple RTK. MEIS1 knockdown leads to a higher growth of clear cell renal cells cancer and non-small-cell lung cancers. However, overexpression of MEIS1 hinders cell growth by decreasing CCND1 expression. Additionally MEIS1 plays a significant role in maintaining the stem cell status of cancerous cells.
This study reveals that NUP98-NSD1 alters progenitors, whereas Lin-progenitors that are in control do not. This research also reveals the role of EZH2 in the regulation of transcription. MEIS1 RNAi studies can be a valuable tool for the elimination of cancer. If MEIS1 is not functioning, the analysis is invalid.
MEIS1's expression is associated with a less favorable overall survival in all forms AML. Particularly MEIS1 expression levels that are high are associated with a lower prognosis for patients suffering from CN-AML. Further research is required to determine if MEIS1's expression is linked with the aging process. These studies are not the only ones that have been conducted. A recent study found that hypoxia can reduce MEIS1 expression in smooth-muscle cells of the pulmonary artery as well as heart.
MEIS1 is a specific human leukemia meelopoietic fusion gene. MEIS1 cooperates to stimulate leukemia cell growth through multiple partners. It also inhibits apoptosis and promotes leukemia cell proliferation. Further, MEIS1 is involved in MLL differentiation and regulation of cycle activity. The NUP98 marker can aid in the diagnosis of leukemias.
The NUP98 marker can be used to identify functional regulatory elements in the human genome. MEIS1 has been identified by micro-RNA-155 as a potential target which activates a gene that causes acute myeloid leukemia. CRISPR-Cas9 technology enables high-throughput screening of regulatory elements that function in the human genome. These studies have provided promising results for research.
This study shows that the NUP98 -NSD1 chimeric protein is composed of a histone-methyltransferase and the chromatin binding domains. The chimeric protein is also known as MEIS1. This chimera joins an N-terminal segment of MLL with Menin and LEDGF. The fusion partner is in contact with LEDGF and ENL and also AF9.
PMID: 8563754 by Borrow J., et al. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9.
PMID: 10087256 by Fontoura B.M.A., et al. A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96.