Olig1 Antibodies

Oligodendrocyte transcription factor 1 (Olig1)

Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to set up that the pMN domain of the embryonic neural tube.

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Gene Information

Mouse
Gene Name:	Olig1
Uniprot:	Q9JKN5
Entrez:	50914

Family

Belongs to:
No superfamily

Alternative Names

BHLHB6; bHLHe21; Class B basic helix-loop-helix protein 6; Class E basic helix-loop-helix protein 21; helix-loop-helix protein, class B, 6; Olig1; oligo1; oligodendrocyte lineage transcription factor 1; oligodendrocyte transcription factor 1; oligodendrocyte-specific bHLH transcription factor 1

Molecular Weight

Mass (kDA):
27.141 kDA

Genomic Context

Mouse
Location:	16|16 C3.3
Sequence:	16;

Tissue Specificity

Expressed specifically in brain.

Diseases

• Nervousness
• Neoplasms
• Demyelinating Diseases
• Demyelination
• Brain Neoplasms
• Multiple Sclerosis
• Sclerosis
• Oligodendroglioma
• Glioma
• Astrocytoma
• Glioblastoma
• Spinal Cord Injuries
• Cell Transformation, Neoplastic

• Experimental Autoimmune Encephalomyelitis
• Autoimmune Reaction
• Down Syndrome
• Malignant Neoplasms
• Anaplastic Oligodendroglioma
• Lymphohistiocytosis, Hemophagocytic
• Anaplastic Astrocytoma

Pathways

• Myelination
• Oligodendrocyte Development
• Oligodendrocyte Differentiation
• Neurogenesis
• Cell Proliferation
• Brain Development
• Regeneration
• Cell Migration
• Gliogenesis
• Cell Differentiation
• Regionalization
• Astrocyte Differentiation
• Localization

• Methylation
• Pathogenesis
• Transport
• Cell Cycle
• Oncogenesis
• Dna Methylation
• Neuroprotection

PTMs

• Phosphorylation
• Methylation

• Nitration
• Acetylation

• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Olig1

Boster Bio - Best Uses Of The OLIG1 Marker

If you're curious about the OLIG1 protein marker, keep reading! This article will go over the CCNB1 as well as OLIG1 markers. Learn how to utilize these markers to your advantage. OLIG1 is versatile and can aid in understanding the function of other proteins such as MBP. This protein marker is an excellent biomarker to study the biological processes occurring in the body.

OLIG1

OLIG1 is a popular marker for oligodendrocytes. The Olig1/2 family of proteins regulates many downstream genes and other factors and may be an immunohistochemical target. The majority of Olig gene families research has been conducted on chickens or rodents. The Olig gene family could be used as an immunohistochemical target. The OLIG1 marker is useful for a variety of reasons, regardless of its role in the pathology process.

The brain is the source of the OLIG1 protein. Specifically, it is a marker of mature OLs. This marker was found in the cortex and corpus callosum of Tet1-cKO mice. Recent studies have shown that cKO mice produced significantly less mature OLs. MBP levels in mice with cKO were significantly lower than in the control mice at three and five days following birth.

Olig1 antibody can be used for various purposes. It is a good way to detect cancer markers. Olig2-C is a superior primary antibody because it recognizes only one band at approximately its predicted molecular weight. However, Olig2-N displays extra bands. In NIH3T3 cells, the cDNA clone is transfected with human Olig1 and immunostaining with an Olig1-specific antibody is the best method to detect this Oligopeptide.

Olig2-C was employed for the study of oligodendroglioma cell lines. It was also useful in diagnosing central neurocytoma. It can also identify glial and neuronal markers. Olig2-C is a good choice in combination with other neuronal markers that are found in the same tissue. It was also used for diagnosis of anaplastic oligodendroglioma.

TET1 regulates epigenetic programming in OL cell lines. It regulates DNA hydroxymethylation and regulates intracellular signaling in OL cells. These genes are necessary for proper OL differentiation. They are essential for animal behavior. The ITPR2 calcium transport system regulates this gene. In addition, it's also essential to differentiate OL lineage cells.

CCNB1

The Cyclin B1 (CCNB1) antibody created by Boster Bio has been tested in the flow Cytometry and Immunofluorescence. This antibody is highly reactive against Rat and Human cells, as well as known negative and positive controls. It is useful to all researchers who wish to analyze Cyclin B1 levels in biological samples. This antibody can be used in different ways.

Hepatocellular carcinoma is the most well-known type of primary liver cancer. Monotherapy is not an option because of the heterogeneity of HCC. However, recent advancements in the treatment of specific genetic events are paving the way for novel approaches to treat and even prevent HCC. Therefore, the aim of this study was to confirm the gene CCNB1 as a biomarker and to determine the connections between CCNB1 expression and antitumor immunity.

OLIG2

The OLIG1 marker is a tool that scientists can use to identify oligodendrocytes in samples. It also plays an important role in the regulation of downstream genes. The OLIG protein family is a potential research area for immunohistochemical studies. The majority of studies that have been conducted on the Olig genes have utilized rodents or chickens as models. The OLIG gene is found in nearly all oligodendrocytes, including glial cells.

The OLIG1 gene is crucial to normal brain development. However it also influences OL differentiation of mice. Three proteins encode the OLIG1 gene: SOX10 (CC1), MBP and CC1. Tet1-deficient mice have significantly lower CC1+ mature OLs than their Tet1-deficient littermates. Adult mice have similar MBP levels as Tet1-deficient mice.

Oligodendrocytes are involved in metabolic and neurodegenerative diseases. They are also involved in neoplasms. Olig2-C is linked to neuropathology and is expected be a factor in the development of these diseases. It is also useful in studying oligodendrocytes and their role in the process of aging and neurodegenerative disorders. In this article, we've described some of the most effective applications of the OLIG1 marker.

The OLIG1 protein is a protein that has a very long amino acid sequence. The human Olig2 gene is a part of an amino acid sequence that allows scientists to calculate the molecular weight of the protein. Olig2-C recognizes one band, while Olig2-N displays extra bands. Both proteins can be detected in the same experiment using the same Olig1 antibody.