ORC5 Antibodies

Origin recognition complex subunit 5 (ORC5)

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent.

The specific DNA sequences that define origins of replication haven't been identified yet. ORC is needed to assemble the pre- replication complex essential to initiate DNA replication.

Gene Information

Human
Gene Name:	ORC5
Uniprot:	O43913
Entrez:	5001

Family

Belongs to:
ORC5 family

Alternative Names

ORC5Lorigin recognition complex, subunit 5-like (yeast); ORC5P; ORC5T; origin recognition complex subunit 5; origin recognition complex, subunit 5 (yeast homolog)-like; origin recognition complex, subunit 5 homolog (yeast); origin recognition complex, subunit 5; origin recognition complex, subunit 5-like

Molecular Weight

Mass (kDA):
50.283 kDA

Genomic Context

Human
Location:	7q22.1-q22.2
Sequence:	7; NC_000007.14 (104126341..104208047, complement)

Tissue Specificity

Abundant in spleen, ovary, prostate, testis, and colon mucosa.

Subcellular Localizations

Nucleus. Chlorosome.

Diseases

• Polyploidy
• Leukemia, Myelocytic, Acute
• Myeloid Leukemia
• Leukemia
• Dysmyelopoietic Syndromes
• Adult Acute Myeloblastic Leukemia
• Genomic Instability
• Malignant Paraganglionic Neoplasm
• Uterine Neoplasms
• Sterility
• Malignant Neoplasms

• Neoplasms
• Fibroid Tumor
• Malaria
• Cytogenetic Abnormality
• Uterine Fibroids
• Aortic Aneurysm, Abdominal

Interacting Proteins

• ORC1
• ORC2
• ORC3
• ORC4

Pathways

• Dna Replication
• Cell Cycle
• S Phase
• Mitosis
• Dna Replication Initiation
• Sister Chromatid Cohesion
• Gene Silencing
• Mating
• M Phase
• Oogenesis
• Metaphase
• Localization
• Spindle Checkpoint

• Heterochromatin Organization
• Heterochromatin Assembly
• Regulation Of Gene Expression
• Cell Cycle Arrest
• Cytokinesis
• Mitochondrial Dna Replication
• Cell Division

PTMs

• Phosphorylation

• Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORC5

Boster Bio - Best Uses Of The ORC5 Marker

Boster Bio offers many flow options. You can find optimization tips and guides if you are unsure what to do next. These guides will guide you through the process of optimizing your experiments. Boster Bio has many different options to help you choose the best one for your research. This article contains more information about Boster Bio.

Steven Boster's history

You're here because you are curious about Steve Boster’s history. We have compiled public records about Steve to help you trace his history. These records include his current home address, previous addresses, email addresses, and known relatives. You can search Steve Boster’s information by state, age, or other criteria. If you're concerned about your friend's safety, you've come to the right place.

Steve Boster was a Joliet, IL native. He was born on February 1, 1944. He was a sales manager for many decades and was a member at Concordia Hall in Staunton. Numerous nieces and nephews are also left behind.

High-affinity primary antibodies

High-affinity primary antibodies are raised against any antigen. These antibodies are highly specific. They can be used to identify and purify antigens. Primary antibodies are often generated by animals as hosts. They are increasingly subject to protein array and knockout validation. Here is a description describing the ORG–G labeled ORC5 markers.

The ORC5-tagged antigen binds to an antibody with a higher affinity in the affinity-maturation analysis. It also interacts with the PDZ domain of PICK1 protein. Using this method, we have demonstrated the specificity of ORC5 antibodies against several different antigens. The following graphs display the results of these tests. The graphs represent the results of three independent experiments.

The ORC complex is composed of six subunits. Each subunit is tightly linked. They are essential for DNA replication. In humans, ORC subunits are nuclear and expressed in both proliferating and non-proliferative tissues. It is unclear if the ORC proteins play an additional role in nonproliferating cells. The ORC complex's subunits co-immunoprecipitate under mild extraction conditions, making detection of the holo complex difficult.

High-affinity primary antibodies that use the ORG5 marker are among the most specific of all the antibody types. They are useful for screening a wide variety of antigens. Moreover, ORC5-based markers can be used for cross-reactive IgG-antibodies. The ORC5 marker should be used to select the ORC5-labeled antibodies.

Moreover, ORC5-labeled antibodies should be highly specific. They should be able identify monovalent antigens even if they are multivalent. The ORC5-labeled antibodies should also be useful for anti-dsDNA-antibodies. This marker is known to increase anti-dsDNA antibodies' sensitivity. The study was carried out in mice under the guidance of the Regierungsprasidium Tubingen licence 1484.

The ORC5 labeled antibody has a high affinity towards self-molecules. It recognizes CD69 in a small percentage of cells. Thus, the ORC5-labeled antibodies are highly specific to their cognate antigen. These antibodies are very useful in the study of autoimmune diseases. These experiments are promising. These results are not specific to peptide antibodies, however.