ORC5 Antibodies

AND ORC5 ELISA kits, ORC5 Proteins

Many biological assays use antibodies to detect ORC5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ORC5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ORC5 antibodies...

We validate the specificity of these antibodies to ORC5 by testing them on tissues known to express ORC5 positively and negatively. Browse below to find the ORC5 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for ORC5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the ORC5 Western Blot Guide

ORC5 Infographic by Boster Bio

All ORC5 Products

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Anti-ORC5L/ORC5 Antibody Picoband®

1 Citations

Western blot analysis of ORC5L/ORC5 using anti-ORC5L/ORC5 antibody (A03676-1)

IF analysis of ORC5L/ORC5 using anti-ORC5L/ORC5 antibody (A03676-1)

Flow Cytometry analysis of U87 cells using anti-ORC5L/ORC5 antibody (A03676-1)

Human, Monkey, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # A03676-1
100 μg/vial

ORC5 Overview

Facts about Origin recognition complex subunit 5.

ORC5 3D structure. Source: alphafold

Origin recognition complex subunit 5 (ORC5)

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent.

The specific DNA sequences that define origins of replication haven't been identified yet. ORC is needed to assemble the pre- replication complex essential to initiate DNA replication.

Gene Information

Human
Gene Name:	ORC5
Uniprot:	O43913
Entrez:	5001

Family

Belongs to:

ORC5 family

Alternative Names

ORC5Lorigin recognition complex, subunit 5-like (yeast); ORC5P; ORC5T; origin recognition complex subunit 5; origin recognition complex, subunit 5 (yeast homolog)-like; origin recognition complex, subunit 5 homolog (yeast); origin recognition complex, subunit 5; origin recognition complex, subunit 5-like

Molecular Weight

Mass (kDA):
50.283 kDA

Genomic Context


Human

Location:	7q22.1-q22.2
Sequence:	7; NC_000007.14 (104126341..104208047, complement)

Tissue Specificity

Abundant in spleen, ovary, prostate, testis, and colon mucosa.

Subcellular Localizations

Nucleus. Chlorosome.

Diseases

Polyploidy
Leukemia, Myelocytic, Acute
Myeloid Leukemia
Leukemia
Dysmyelopoietic Syndromes
Adult Acute Myeloblastic Leukemia
Genomic Instability
Malignant Paraganglionic Neoplasm
Uterine Neoplasms
Sterility
Malignant Neoplasms

Neoplasms
Fibroid Tumor
Malaria
Cytogenetic Abnormality
Uterine Fibroids
Aortic Aneurysm, Abdominal

Interacting Proteins

ORC1
ORC2
ORC3
ORC4

Pathways

Dna Replication
Cell Cycle
S Phase
Mitosis
Dna Replication Initiation
Sister Chromatid Cohesion
Gene Silencing
Mating
M Phase
Oogenesis
Metaphase
Localization
Spindle Checkpoint

Heterochromatin Organization
Heterochromatin Assembly
Regulation Of Gene Expression
Cell Cycle Arrest
Cytokinesis
Mitochondrial Dna Replication
Cell Division

PTMs

Phosphorylation

Deacetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORC5

References

PMID: 9829972 by Tugal T., et al. The Orc4p and Orc5p subunits of the Xenopus and human origin recognition complex are related to Orc1p and Cdc6p.

PMID: 9417919 by Ishiai M., et al. Isolation of human and fission yeast homologues of the budding yeast origin recognition complex subunit ORC5: human homologue (ORC5L) maps to 7q22.