OXCT1 Antibodies

AND OXCT1 ELISA kits, OXCT1 Proteins

Many biological assays use antibodies to detect OXCT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OXCT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OXCT1 antibodies...

We validate the specificity of these antibodies to OXCT1 by testing them on tissues known to express OXCT1 positively and negatively. Browse below to find the OXCT1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OXCT1 Infographic by Boster Bio

All OXCT1 Products

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Product

Figures

Specificity

Applications

Price

Anti-OXCT1/SCOT Antibody Picoband®

Human, Monkey, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A07229-1
100 μg/vial

OXCT1 (NM_000436) Human Recombinant Protein

$813
Cat # PROTP55809
20 µg

OXCT1 (NM_000436) Human Over-expression Lysate

Human

$628
Cat # LS005019
100 µg

OXCT1 Overview

Facts about Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial.

OXCT1 3D structure. Source: alphafold

Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (OXCT1)

Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate.

Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. .

Gene Information

Human
Gene Name:	OXCT1
Uniprot:	P55809
Entrez:	5019

Family

Belongs to:

3-oxoacid CoA-transferase family

Alternative Names

3-oxoacid CoA transferase 1,3-oxoacid CoA transferase; EC 2.8.3; EC 2.8.3.5; SCOTmitochondrial

Molecular Weight

Mass (kDA):
56.158 kDA

Genomic Context


Human

Location:	5p13.1
Sequence:	5; NC_000005.10 (41730065..41870535, complement)

Tissue Specificity

Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Neoplasms
Neoplasm Metastasis
Malnutrition
Tumor Progression
Malignant Neoplasm Of Breast
Glioma
Malignant Paraganglionic Neoplasm
Hypoxia
Advanced Malignant Neoplasm
Tumor Angiogenesis

Malignant Neoplasms
Huntington Disease
Hypoglycemia
Ketosis

Pathways

Autophagy
Tricarboxylic Acid Cycle
Cell Death
Lactate Oxidation
Angiogenesis
Fatty Acid Oxidation

Glycolysis

PTMs

Phosphorylation

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OXCT1

References

PMID: 8751852 by Kassovska-Bratinova S., et al. Succinyl CoA:3-oxoacid CoA transferase (SCOT): human cDNA cloning, human chromosomal mapping to 5p13, and mutation detection in a SCOT- deficient patient.

PMID: 10964512 by Fukao T., et al. Succinyl-CoA:3-ketoacid CoA transferase (SCOT): cloning of the human SCOT gene, tertiary structural modeling of the human SCOT monomer, and characterization of three pathogenic mutations.