PDE12 Antibodies

AND PDE12 ELISA kits, PDE12 Proteins

Many biological assays use antibodies to detect PDE12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE12 antibodies...

We validate the specificity of these antibodies to PDE12 by testing them on tissues known to express PDE12 positively and negatively. Browse below to find the PDE12 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE12 Infographic by Boster Bio

All PDE12 Products

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Specificity

Applications

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PDE12 (NM_177966) Human Recombinant Protein

Coomassie blue staining of purified PDE12 protein

$1249
Cat # PROTQ6L8Q7
20 µg

PDE12 (NM_177966) Human Over-expression Lysate

Human

$960
Cat # LS201626
20 µg, 100 µg

Anti-PDE12 Antibody Picoband®

Western blot analysis of PDE12 using anti-PDE12 antibody (A10688-1)

Flow Cytometry analysis of Caco-2 cells using anti-PDE12 antibody (A10688-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A10688-1
100 µg/vial

PDE12 Overview

Facts about 2',5'-phosphodiesterase 12.

PDE12 3D structure. Source: alphafold

2',5'-phosphodiesterase 12 (PDE12)

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates called 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to generate AMP and ATP.

Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the The 2-5A system that is among the important pathways for antiviral and antitumor functions induced by interferons (IFNs).

Gene Information

Human
Gene Name:	PDE12
Uniprot:	Q6L8Q7
Entrez:	201626

Family

Belongs to:

CCR4/nocturin family

Alternative Names

2'-PDE; phosphodiesterase 12

Molecular Weight

Mass (kDA):
67.352 kDA

Genomic Context


Human

Location:	3p14.3
Sequence:	3; NC_000003.12 (57556274..57656495)

Tissue Specificity

Ubiquitous.

Subcellular Localizations

Mitochondrion matrix.

Diseases

Neurodegenerative Disorders

Pathways

Translation

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE12

References

PMID: 15231837 by Kubota K., et al. Identification of 2'-phosphodiesterase, which plays a role in the 2- 5A system regulated by interferon.

PMID: 21245038 by Poulsen J.B., et al. Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover.