Progesterone receptor Antibodies

Progesterone receptor (PGR)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Based on the isoform, progesterone receptor functions as transcriptional activator or repressor.

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Gene Information

Human
Gene Name:	PGR
Uniprot:	P06401
Entrez:	5241

Family

Belongs to:
nuclear hormone receptor family

Alternative Names

NR3C3; NR3C3PRNuclear receptor subfamily 3 group C member 3; PGR; Progesterone R; progesterone receptor; ProgesteroneR

Molecular Weight

Mass (kDA):
98.981 kDA

Genomic Context

Human
Location:	11q22.1
Sequence:	11; NC_000011.10 (101029624..101130681, complement)

Tissue Specificity

In reproductive tissues the expression of isoform A and isoform B varies as a consequence of developmental and hormonal status. Isoform A and isoform B are expressed in comparable levels in uterine glandular epithelium during the proliferative phase of the menstrual cycle. Expression of isoform B but not of isoform A persists in the glands during mid-secretory phase. In the stroma, isoform A is the predominant form throughout the cycle. Heterogeneous isoform expression between the glands of the endometrium basalis and functionalis is implying region- specific responses to hormonal stimuli.

Subcellular Localizations

Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases.; [Isoform A]: Nucleus. Cytoplasm. Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane.

Diseases

• Malignant Neoplasms
• Malignant Neoplasm Of Breast
• Mammary Neoplasms
• Neoplasms
• Carcinoma
• Endometrial Polyp
• Adenocarcinoma
• Leukemia
• Ovarian Neoplasm
• Malignant Paraganglionic Neoplasm
• Neoplasm Metastasis
• Malignant Neoplasm Of Ovary
• Endometrial Carcinoma

• Carcinogenesis
• Endometriosis, Site Unspecified
• Infertility
• Acute Lymphocytic Leukemia
• Ductal Breast Carcinoma
• Endometrial Neoplasms
• Peste Des Petits Ruminants Infection

Interacting Proteins

• CUEDC2
• ESR1
• STAT3

Pathways

• Ovulation
• Methylation
• Secretion
• Localization
• Dna Methylation
• Cell Proliferation
• Pathogenesis
• Embryo Implantation
• Fertilization
• Regeneration
• Transport
• Parturition
• Cell Growth

• Angiogenesis
• Cell Death
• Luteinization
• Spermatogenesis
• Cell Differentiation
• Lactation
• Somatic Embryogenesis

PTMs

• Methylation
• Phosphorylation
• Cleavage
• Demethylation

• Acetylation
• Oxidation
• Deacetylation
• Prenylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PGR

Best Uses Of The PGR Marker

A multichannel pipette allows you to disperse just a tiny volume of aqueous solution with the press of a button. Multichannel pipettes permit you to disperse a sample into multiple volumes without the need to repeat the procedure. For larger amounts of samples multichannel pipettes are recommended. You can share the results you get from products that are not validated with other researchers and receive credit for the product.

Multichannel pipettes

Multichannel pipettes are a great option to accelerate your work process or increase the efficiency of your laboratory. These innovative devices let you fill multiple tubes with liquid and ensure uniform accuracy across all channels. However, they require additional care to set the tips and seat them properly. To avoid these issues, opt for a multichannel pipestte that is light and easily autoclavable. The manifold is the pipette's head and is where the tip cones are. A pipette with autoclave capability makes it easy to sterilize or repair and universal tips can reduce time and stress.

Multichannel pipettes are made of removable rubber inserts in color-coded rubber which can be labeled according to volume. You can also label pipettes by their number of channels or capacity, making choosing the right one much easier. They are designed with a minimal force of pipetting making them easier to use, and they maintain unbeatable accuracy. Multichannel pipettes can be adjusted by rotating the lower body 360degrees.

Despite the advantages of using multichannel pipettes for transferring several samples at the same time, they do have some shortcomings. The pipettes' tubing may become porous or frail with time, which increases the risk of leaks. Researchers have to perform hundreds of transfers with the same pipette before they can make use of it to collect larger volumes of samples. Therefore, it is crucial to know the differences between microflutes and well plates, and how the two types of devices work together.

CAPPSolo multichannel pipettes are designed with top-quality features. They're not expensive, yet they provide top quality and reliability. CAPPSolo multichannel pipettes are a good choice for many labs. They are guaranteed to meet industry standards of accuracy and precision throughout their usage cycles. To help avoid accidental falls they also feature a color-coded soft-grip fingers rest. They are also affordable. You'll save time, money, and headaches by investing in a high-end multichannel pipette.

A multichannel pipette can help you quickly transfer samples, add reagent to all wells, and decrease repetitive motion. They can be fitted with 384-well and 96-well PCR assay plates, which means you can use them for your work. Since they can be programmed, they're incredibly easy to use. If you're willing to change to and get a multichannel pipette, you can and start maximizing your productivity.

It is crucial to have the correct instrument, and the appropriate technique, in order to accurately and effectively measure liquids. Pipettes are essential lab equipment for accurate measurement, and using the wrong method can have a negative effects on the results. The most important thing to consider when testing with pipettes is the accuracy and reproducibility. Before making a decision, make sure you're familiar with the various apparatus. It is a smart decision. You can use all the lab equipment to assist you in your research. Make sure to invest in the best equipment.

Multichannel pipettes can be utilized to collect large quantities of samples

A multichannel pipette is a large piece of equipment for laboratory use that allows the transfer of multiple samples at once. This improves the consistency of the pipetting procedure and reduces the amount of time needed to transfer an item. But multichannel pipettes are not without their limitations. One of these drawbacks is that the pipette's tubing may become porous and brittle with time, leading to leaks inside the pipettes.

Multichannel pipettes are ideal for large sample transfers. These pipettes are equipped with a number of channels and different kinds of tips. Some pipettes have more than one channel, while others have just two. If you're working with an enormous number of samples, a multichannel pipette will be the best choice. It's also cheaper than one-channel pipette.

When purchasing a multichannel pipestte ensure you get one that is suitable for your needs. Certain pipettes are more precise than others and others have more channels. Think about the amount of channels you need to choose the best one. Also, consider the size and type of the sample you're working with. If the samples are small, a multichannel pipette might be the best option.

Multichannel pipettes are electronic devices that permit researchers to draw liquid from multiple vials at once. These devices are available in various designs and sizes, but all serve the same purpose in making pipetting easier quicker, more efficient and more precise. It ensures consistency in a sample drawing by preventing repetitive motion. Multichannel pipette can be used to fill multiple small samples at once.

Pipettes are a vital tool in every lab. They are used for transferring and measuring liquid samples, and are an essential part of most research projects. The job at to be completed will determine the appropriate pipette. Certain pipettes are designed for smaller amounts, while some are more suitable for larger samples. A multichannel pipette is ideal for assays with high-throughput. There's a broad selection of pipettes at CAPP.

Multichannel pipettes work best when you are using multiple pipettes-mounted devices to process large quantities of sample. To avoid cross contamination air displacement pipettes feature an inflatable cushion between the sample container and the barrel. They also lower the risk of repetitive strain injuries because they do not having knobs or plungers. The barrels of multichannel pipettes are also susceptible to contamination, and must be pre-wetted to prevent spills that could happen accidentally.

Pipettes with multiple channels are the most effective. They can hold many liquids, including aqueous solutions and samples. To facilitate mixing samples they are equipped with various tips. Single-channel micropipettes may be used in laboratories with low to medium quantities of samples. Single-channel pipettes are best for laboratory work related to molecular biology, immunology, cell culture and DNA amplification.

Different tips are available for micropipettes. When you are aspirating a sample, hold the plunger at its first stop to ensure a sufficient volume, and then release the plunger slowly and with care to avoid overloading the tip. The pipettes should be held at the right angle to ensure uniform dispensing of liquid. It is recommended to hold the pipettes with a 15-degree angle when dispensing samples. This will ensure that the tip is at the right angle.

A multichannel pipette should be calibrated at room temperature before you begin working with it. This prevents the air cushion from becoming temperature-dependent and affecting the accuracy of your results. Pre-wetting the tip of your pipette is a great way to moisten the air cushion. To accomplish this, aspirate the nominal volume three times and dispense it three times to make the tip more moist. This is a crucial step to ensure that you maintain a the same hydrostatic pressure at tip of the pipette.

There are many kinds and styles of micropipettes. Micropipettes fall into two categories, Positive Displacement Pipettes and Air Displacement Micropipettes. Each type has specific advantages. It is also better to purchase one of each type, as the micropipette's size and weight is not a problem. If you're unsure which one you would like, it is a good idea to buy an initial kit.