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- Table of Contents
Facts about PHD finger protein 21B.
Human | |
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Gene Name: | PHF21B |
Uniprot: | Q96EK2 |
Entrez: | 112885 |
Belongs to: |
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No superfamily |
BHC80L; FLJ34161; KIAA1661; PHD finger protein 21B; PHD finger protein 4; PHF4
Mass (kDA):
57.455 kDA
Human | |
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Location: | 22q13.31 |
Sequence: | 22; NC_000022.11 (44881162..45010005, complement) |
What Are The Best Uses for the PHF21B gene? PHF21B may be expressed by tumor-stem cells. Tumor stem cells can express the following proteins in cancer: FERMT1, RPS2, CXADR LMF1, POLR2F, and CXADR FERMT1. In addition, this gene can also be expressed by cancer-causing glioma cells.
Astrocytes from tumors express the PHF21B protein. It may lack or express low levels astrocyte genes such HEY1CAM. This gene can be used for the identification of tumor oligodendrocytes. Several tumor oligodendrocytes express PHF21B. There are some limitations to the uses of PHF21B.
The stem cell signature gene, PHF21B, is often referred too. It is often associated with other genes, including SOX4, HNRNPh2, PTPRS, CD24, TFDP2, FBLIM1, ZBTB8A, NEK5, TNFAIP8L1, and SET. It can also be expressed by hematopoietic or adult stem cells depending on the gene.
PHF21B could be a prognostic biomarker for prostate carcinoma. PHF21B expression was increased in human PCa tissues, suggesting that it could be involved in the progression and control of PCa. It has been shown to be associated with tumor stage, total PSA level, and other factors. PHF21B is a promising candidate for prostate-cancer target therapy.
The PHF21B gene is found in the hippocampus and several other parts of the brain. Studies have shown differential splicing of this gene can contribute to the development of prostate cancer. It also regulates gene expression in the hippocampal region. The expression of Phf21B in the hippocampal region of animals that are resilient to chronic stress was reduced.
The PHF21B gene is upregulated in prostate cancer cells, and tumors with high levels of this gene have been associated with a poorer prognosis. Overexpression of PHF21B was found in PCa cell line lines. However, silencing reduced tumor spheroids. The PHF21B gene suppresses repressors of the Wnt/b-catenin signaling cascade.
The PHF21B gene acts in a transcriptional repressor role and regulates negative modulators Wnt/b–catenin signaling. Transduced PCa cells expressing PHF21B had a decreased expression of SFRP1 or SFRP2, while PHF21B silenced PCa cells expressed SFRP1/SFRP2 in a dose-dependent way. These studies also revealed that PHF21B induced cancer progression.
The PHF21B gene has several uses in medicine, including in the detection of cancer. It is a key gene that doctors use to identify tumors or tissues. These genes are also useful in monitoring drug resistance. This article will discuss several of these uses. These are some of the most popular. Find out the best way to use this particular gene. We have provided a list of some of the most popular methods so that you can make the best decision regarding your cancer diagnosis.
Cancer stem cells express PHF21B. The tumor cells could not express certain genes, or they may have a reduced expression. Several studies have shown that cancer cells that express this gene are better able to respond to chemotherapy. Although tumors without this gene are more aggressive than those with it, other types of cancer are more likely to respond to therapy that contains the PHF21B gene.
The tumor stem cell is responsible for the expression of the PHF21B genetic code. The PHF21B gene is expressed by a variety of tumor cells including glioma, sarcoma, and prostate cancer. This marker can be used for identifying the tumor stem cell. Some proteins expressed by tumor stem cells are aLG9, AP3S1, CNTNAP2, GFRA1, IGSF8, NLGN3, RASD1, SDC3, SEC24B, TTLL5, and SDF-1.
The PHF21B Gene is also known to be a stem cell signature genes. It is a transcription molecule that is expressed by stem cell-derived stem cells. It is found in oligodendrocytes with different characteristics. The tumor oligodendrocyte is devoid of expression of CRYAB and PAPLN, CA12 and BBOX1, SSTR2, RASL10A and HEY1CAM.
The PHF21B marker in human cancers is highly specific. It is expressed from tumor stem cells. Depending on the type of tumor, the PHF21B gene can either be expressed in low levels or in high levels. Here are the best uses of the PHF21B marker:
The PHF21B gene causes differences in the expression genes in many brain areas, including the hippocampal. Phf21b hippocampal expression was reduced in mice with chronic stress resistance. This gene is expressed in the hippocampal in two forms. One isoform has an additional 5'-coding exon. The other isoform has an alternate acceptor. The encoded form is shorter than the others.
Tumor cells that have lost the ability to express astrocyte marker genes, or ceased to do so, will produce the PHF21B gene. The presence of this gene is strongly linked to tumor cell activity. Researchers have previously demonstrated that PHF21B is a useful marker for detecting these types of cancer. In addition, it may also be a useful biomarker for determining the potential risks associated with cancer.
This gene has been identified as a signature gene for stem cells. The PHF21B genetic expression can be found in many tissues including the breast, testes, and gastrointestinal tract. It can target and identify stem cells when combined with other gene targets. The most common gene targets include SOX4, HNRNPh2, PTPRS, CD24, TFDP2, FBLIM1, ZBTB8A, NEK5, TNFAIP8L1, SET, and CCND2.
PMID: 15461802 by Collins J.E., et al. A genome annotation-driven approach to cloning the human ORFeome.
PMID: 14702039 by Ota T., et al. Complete sequencing and characterization of 21,243 full-length human cDNAs.