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Pik3ap1 Antibodies
AND Pik3ap1 ELISA kits, Pik3ap1 Proteins
Many biological assays use antibodies to detect Pik3ap1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pik3ap1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pik3ap1 antibodies...
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Pik3ap1 Infographic by Boster Bio
All Pik3ap1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M08114-1
100 µl
Cat # M08114-1
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M08114
100 µl
Cat # M08114
100 µl
Pik3ap1 Overview
Facts about Phosphoinositide 3-kinase adapter protein 1.
Phosphoinositide 3-kinase adapter protein 1 (Pik3ap1)
Signaling adapter that contributes to B-cell growth by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary function to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1.
Otherwise, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Pik3ap1 |
| Uniprot: | Q9EQ32 |
| Entrez: | 83490 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
1810044J04Rik; B cell adaptor protein; BCAP; BCAPB-cell adapter for phosphoinositide 3-kinase; B-cell phosphoinositide 3-kinase adapter protein 1; FLJ35564; phosphoinositide 3-kinase adapter protein 1; phosphoinositide-3-kinase adaptor protein 1; Pik3ap1; RP11-34E5.3
Molecular Weight
Mass (kDA):
90.928 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 19|19 C3 |
| Sequence: | 19; |
Tissue Specificity
Predominantly expressed in spleen (at protein level). Expressed at lower levels in thymus, liver and lung. Expressed in B-cells, macrophages and natural killer (NK) cells.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Endoplasmic Reticulum Stress
- Carcinogenesis
- Neoplasms
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Inflammation
- Neoplasm Metastasis
- Metastatic Malignant Neoplasm To The Lymph Node
- Malignant Neoplasm Of Breast
- Immunologic Tolerance
- Inflammatory Response
Pathways
- Cell Development
- Cytokine Production
- Cell Migration
- Cell Proliferation
- Cytokine Secretion
- Immune Response
- Localization
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pik3ap1
bosterbio.com/bosterbio-gene-info-cards/Pik3ap1
References
PMID: 11163197 by Okada T., et al. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
PMID: 11781242 by Inabe K., et al. Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3- kinase is required for Akt activation in response to CD19 engagement.