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- Table of Contents
Facts about Placenta-specific protein 9.
Human | |
---|---|
Gene Name: | PLAC9 |
Uniprot: | Q5JTB6 |
Entrez: | 219348 |
Belongs to: |
---|
PLAC9 family |
MGC104710; placenta-specific 9; placenta-specific protein 9
Mass (kDA):
10.309 kDA
Human | |
---|---|
Location: | 10q22.3 |
Sequence: | 10; NC_000010.11 (80131661..80145359) |
Secreted.
Anti-Cyclin D1 antibodies are one of the most important compounds in molecular biology. It has been widely used for immunohistochemistry and Western Blotting. There are some limitations to using the anti-Cyclin D1 antibodies. This article will discuss its best uses. Find out more. We are delighted that you are interested to learn more about our research products.
CYCLIN D1, also called BCL-1, regulates the cell's cycle. It is also a potential proto-oncogene. Antibodies to CYCLIN D1 can neutralize its activity both in vitro, and in vivo. CyclinD1 is overexpressed by about 60% of mantle-cell lymphomas. This marker is important in distinguishing mantle lymphomas from other types. Hairy cell leukemia and plasma cell lymphoma are weakly expressed in CYCLIN D1 and CCND1.
PLAC8, another protein marker for CYCLIN D1, is also available. It has been linked to obesity and type 2 diabetes. It regulates cell-cycle pathway and promotes invasion and migration. These processes are not directly influenced by the protein. PLAC8, a nuclear protein is a candidate for type 2 and type 2 diabetes. It is also involved with the development type 2 diabetes and obesity.
PLAC8 is an important component of the EMT pathway, even though it is associated with BC. Its overexpression can increase cell proliferation and migrate, while also inhibiting BC-cell apoptosis. This new protein acts on the PI3K/AKT/NFKB pathway, revealing a molecular pathway. This protein may also have implications for the development of therapies for cancer.
Anti-Cyclin D1 antibody targets tumor cells that have high levels of PLAC8. PLAC8 activation promotes tumor cell growth at both the cellular level and in tissues. It is also known that it activates the Wnt/bcatenin pathway. PLAC8 could thus be a promising therapeutic target to treat lung cancer.
A significant proportion of human tumors express the CCND1 gene. CCND1 overexpression can maintain a tumorigenic phenotype. Moreover, cyclin D1-antisense may be able revert malignant cells back to their more normal state. Thus, CCND1 and related proteins may be important biomarkers or cancer therapies.
PMID: 15164054 by Deloukas P., et al. The DNA sequence and comparative analysis of human chromosome 10.