Pnpt1 Antibodies

AND Pnpt1 ELISA kits, Pnpt1 Proteins

Many biological assays use antibodies to detect Pnpt1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pnpt1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pnpt1 antibodies...

We validate the specificity of these antibodies to Pnpt1 by testing them on tissues known to express Pnpt1 positively and negatively. Browse below to find the Pnpt1 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Pnpt1 Infographic by Boster Bio

All Pnpt1 Products

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Specificity

Applications

Price

Anti-PNPase PNPT1 Antibody

Western Blot analysis of various cells using PNPase Polyclonal Antibody diluted at 1:1000

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PNPT1 Antibody

Human, Mouse

ELISA, IF, IHC, WB

$380
Cat # A05460
100ul

Anti-PNPT1 Antibody Picoband®

Western blot analysis of PNPT1 using anti-PNPT1 antibody (A05460-1)

IHC analysis of PNPT1 using anti-PNPT1 antibody (A05460-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A05460-1
100 μg/vial

Human PNPT1 Recombinant Protein

SDS-PAGE

$250
Cat # PROTQ8TCS8
Starting from 4ug

PNPT1 (NM_033109) Human Over-expression Lysate

Human

$628
Cat # LS087178
20 µg, 100 µg

Pnpt1 Overview

Facts about Polyribonucleotide nucleotidyltransferase 1, mitochondrial.

Polyribonucleotide nucleotidyltransferase 1, mitochondrial (Pnpt1)

RNA-binding protein implicated in numerous RNA metabolic processes. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity.

Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double- stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for proper processing and polyadenylation of mitochondrial mRNAs.

Gene Information

Mouse
Gene Name:	Pnpt1
Uniprot:	Q8K1R3
Entrez:	71701

Family

Belongs to:

polyribonucleotide nucleotidyltransferase family

Alternative Names

DKFZp762K1914; EC 2.7.7; EC 2.7.7.8; mitochondrial; OLD35; old-35; PNPase 1; PNPase old-35; PNPase; Polynucleotide phosphorylase 1; Polynucleotide phosphorylase-like protein; polyribonucleotide nucleotidyltransferase 1

Molecular Weight

Mass (kDA):
85.683 kDA

Genomic Context


Mouse

Location:	11\|11 A3.3
Sequence:	11;

Diseases

Melanoma
Malignant Neoplasms
Neoplasms
Inflammation
Growth Arrest
Chronic Inflammation
Acute Lymphocytic Leukemia
Growth Retardation
Leukemia
Retinal Dystrophies
Exposure To Ionizing Radiation
Malignant Neoplasm Of Breast
Neurodegenerative Disorders

Mitochondrial Diseases
Myeloid Leukemia, Chronic
Parkinson Disease
Leukemia, Myelocytic, Acute
Cytomegalovirus Infections
Myeloid Leukemia
Hereditary Nonpolyposis Colorectal Cancer

Pathways

Senescence
Cellular Senescence
Aging
Cell Cycle
Cell Cycle Arrest
Cell Growth
Induction Of Apoptosis
G1 Phase
Localization
Response To Interferon-alpha
Translation

S Phase
Mitochondrial Translation
Rna Processing
Pathogenesis
Rna Polyadenylation

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Pnpt1

References

PMID: 12419256 by Raijmakers R., et al. Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring.

PMID: 16966381 by Chen H.W., et al. Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis.