This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
PPIE Antibodies
AND PPIE ELISA kits, PPIE Proteins
Many biological assays use antibodies to detect PPIE, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPIE in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPIE antibodies...
Designing a Western blot for PPIE? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PPIE Western Blot GuidePPIE Infographic by Boster Bio
All PPIE Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M08021
100 μg/vial
Cat # M08021
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M08021-1
100 μg/vial
Cat # M08021-1
100 μg/vial
Human, Mouse
ELISA, Flow Cytometry, IP, IF, ICC, WB
$370
Cat # A08021-1
100 μg/vial
Cat # A08021-1
100 μg/vial
PPIE Overview
Facts about Peptidyl-prolyl cis-trans isomerase E.
Peptidyl-prolyl cis-trans isomerase E (PPIE)
Involved in pre-mRNA splicing as part of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA- binding and PPIase activities (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20460131).
Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107, PubMed:18258190, PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251).
Gene Information
| Human | |
|---|---|
| Gene Name: | PPIE |
| Uniprot: | Q9UNP9 |
| Entrez: | 10450 |
Family
| Belongs to: |
|---|
| cyclophilin-type PPIase family |
Alternative Names
Cyclophilin E; cyclophilin-33; CYP33; CyP-33; EC 5.2.1.8; MGC111222; MGC3736; peptidyl-prolyl cis-trans isomerase E; peptidylprolyl isomerase E (cyclophilin E); PPIase E; Rotamase E
Molecular Weight
Mass (kDA):
33.431 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.2 |
| Sequence: | 1; NC_000001.11 (39738845..39765698) |
Tissue Specificity
Found in all the examined tissues including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Subcellular Localizations
Nucleus.
Diseases
- Leukemia
- Chromosomal Translocation
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Non-neoplastic Disorder
- Confusion
- Lung Diseases
- Carcinoma
- Xeroderma Pigmentosum Complementation Group A
- Pulmonary Emphysema
Interacting Proteins
- AQR
- KMT2A
- XAB2
Pathways
- Regulation Of Gene Expression
- Protein Folding
- Viral Replication
- Dna Methylation
- Hypersensitivity
- Tropism
- Methylation
- Histone H3 Acetylation
- Posttranscriptional Regulation Of Gene Expression
- Cell Cycle
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPIE
bosterbio.com/bosterbio-gene-info-cards/PPIE
References
PMID: 9747881 by Kim J.-O., et al. Co-amplification of a novel cyclophilin-like gene (PPIE) with L-myc in small cell lung cancer cell lines.
PMID: 8977107 by Mi H., et al. A nuclear RNA-binding cyclophilin in human T cells.