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PRDM14 Antibodies
AND PRDM14 ELISA kits, PRDM14 Proteins
Many biological assays use antibodies to detect PRDM14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRDM14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRDM14 antibodies...
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PRDM14 Infographic by Boster Bio
All PRDM14 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03870-2
100 μg/vial
Cat # A03870-2
100 μg/vial
PRDM14 Overview
Facts about PR domain zinc finger protein 14.
PR domain zinc finger protein 14 (PRDM14)
Transcription factor which has both negative and positive roles on transcription. Required for the maintenance of emryonic stem cell identity and the reacquisition of pluripotency in somatic cells.
May play a vital role in germ cell development at two levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and effective epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is needed for the functions in pluripotency and germ cell formation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PRDM14 |
| Uniprot: | Q9GZV8 |
| Entrez: | 63978 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
MGC59730; PFM11; PR domain containing 14; PR domain zinc finger protein 14; PR domain-containing protein 14; PRDM14; PR-domain zinc finger protein 14
Molecular Weight
Mass (kDA):
64.062 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q13.3 |
| Sequence: | 8; NC_000008.11 (70051613..70071252, complement) |
Tissue Specificity
Expressed in embryonic stem cells. Tends to be overexpressed in breast cancer (at protein level).
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Invasive Breast Carcinoma
- Carcinoma
- Carcinoma In Situ
- Noninfiltrating Intraductal Carcinoma
- Cell Transformation, Neoplastic
- Cardiomyopathy, Familial Idiopathic
- Acute Lymphocytic Leukemia
- Leukemia
Interacting Proteins
- ATPAF2
- BEX2
- CBFA2T2
- CDCA7L
- EIF4E2
- GPATCH2L
- HEXIM2
- Hoxa1
- HSPB7
- PRKAB2
Pathways
- Cell Development
- Germ Cell Development
- Gastrulation
- Methylation
- Cell Growth
- Gene Silencing
- Dna Demethylation
- Spermatogenesis
- Demethylation
- Senescence
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRDM14
bosterbio.com/bosterbio-gene-info-cards/PRDM14
References
PMID: 17942894 by Nishikawa N., et al. Gene amplification and overexpression of PRDM14 in breast cancers.
PMID: 20953172 by Chia N.Y., et al. A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.