Histone-lysine N-methyltransferase PRDM9 (PRDM9)

Histone methyltransferase that especially trimethylates'Lys-4' of histone H3 during meiotic prophase and is essential for proper meiotic progression. Does not have the capacity to mono- and dimethylate'Lys-4' of histone H3.

H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).