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- Table of Contents
Facts about Histone-lysine N-methyltransferase PRDM9.
H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes during early meiotic prophase (By similarity).
Human | |
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Gene Name: | PRDM9 |
Uniprot: | Q9NQV7 |
Entrez: | 56979 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
EC 2.1.1.43; histone-lysine N-methyltransferase PRDM9; minisatellite binding protein 3 (115kD); minisatellite binding protein 3, 115kDa; PFM6MEISETZ; PR domain containing 9; PR domain zinc finger protein 9; PR domain-containing protein 9; PRMD9; ZNF899
Mass (kDA):
103.376 kDA
Human | |
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Location: | 5p14.2 |
Sequence: | 5; NC_000005.10 (23507155..23528093) |
Nucleus. Chromosome. Localizes in nuclei of pre-leptotene, leptotene, and early to mid-zygotene spermatocytes.
PMID: 10668202 by Jiang G.L., et al. The yin-yang of PR-domain family genes in tumorigenesis.
PMID: 24634223 by Eram M.S., et al. Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.