DNA-directed primase/polymerase protein (PRIMPOL)

DNA primase and DNA polymerase capable to initiate de novo DNA synthesis using dNTPs. Shows a high ability to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA.

Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, suggesting it might be involved in DNA tolerance during the replication of mitochondrial DNA.