26S proteasome non-ATPase regulatory subunit 14 (PSMD14)

Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays an integral role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins, which might impair cellular capabilities, and by eliminating proteins whose functions are no longer required.

Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves'Lys-63'-linked polyubiquitin chains within the complex.