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- Table of Contents
PSMD14 Antibodies
AND PSMD14 ELISA kits, PSMD14 Proteins
Many biological assays use antibodies to detect PSMD14, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PSMD14 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PSMD14 antibodies...
Designing a Western blot for PSMD14? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PSMD14 Western Blot GuideDesigning an IHC experiment for PSMD14? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PSMD14 IHC GuidePSMD14 Infographic by Boster Bio
All PSMD14 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A06584-1
100 µg/vial
Cat # A06584-1
100 µg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M06584
100 μl/vial
Cat # M06584
100 μl/vial
PSMD14 Overview
Facts about 26S proteasome non-ATPase regulatory subunit 14.
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays an integral role in the maintenance of protein homeostasis by eliminating misfolded or damaged proteins, which might impair cellular capabilities, and by eliminating proteins whose functions are no longer required.
Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves'Lys-63'-linked polyubiquitin chains within the complex.
Gene Information
| Human | |
|---|---|
| Gene Name: | PSMD14 |
| Uniprot: | O00487 |
| Entrez: | 10213 |
Family
| Belongs to: |
|---|
| peptidase M67A family |
Alternative Names
EC 3.1.2.15; EC 3.4.19.-; pad1; POH126S proteasome non-ATPase regulatory subunit 14,26S proteasome regulatory subunit RPN11; proteasome (prosome, macropain) 26S subunit, non-ATPase, 14; Rpn11; RPN11,26S proteasome-associated PAD1 homolog 1
Molecular Weight
Mass (kDA):
34.577 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q24.2 |
| Sequence: | 2; NC_000002.12 (161308425..161411717) |
Tissue Specificity
Widely expressed. Highest levels in heart and skeletal muscle.
Diseases
- Carcinoma
- Neoplasms
- Fanconi Anemia
- Nephrotic Syndrome
- Intestinal Schistosomiasis
- Anemia
- Nerve Degeneration
- Neurodegenerative Disorders
- Malignant Tumor Of Cervix
- Parkinson Disease
Interacting Proteins
- DPY30
- FAM9B
- MEOX2
- PSMD7
Pathways
- Cell Proliferation
- Cell Cycle
- Proteolysis
- Rna Interference
- Senescence
- Osteoclast Differentiation
- Drug Resistance
- Sensitization
- Dna Repair
PTMs
- Ubiquitination
Research Areas
- Core ESC-Like Genes
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PSMD14
bosterbio.com/bosterbio-gene-info-cards/PSMD14
References
PMID: 9374539 by Spataro V., et al. Resistance to diverse drugs and ultraviolet light conferred by overexpression of a novel human 26 S proteasome subunit.
PMID: 1317798 by Kanayama H.O., et al. Demonstration that a human 26S proteolytic complex consists of a proteasome and multiple associated protein components and hydrolyzes ATP and ubiquitin-ligated proteins by closely linked mechanisms.