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- Table of Contents
Facts about Prostaglandin E2 receptor EP1 subtype.
May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in a variety of tissues.
Human | |
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Gene Name: | PTGER1 |
Uniprot: | P34995 |
Entrez: | 5731 |
Belongs to: |
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G-protein coupled receptor 1 family |
EP1; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1 (subtype EP1), 42kD; prostaglandin E receptor 1 (subtype EP1), 42kDa; prostaglandin E receptor 1, subtype EP1; prostaglandin E2 receptor EP1 subtype; Prostanoid EP1 receptor; PTGER1
Mass (kDA):
41.801 kDA
Human | |
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Location: | 19p13.12 |
Sequence: | 19; NC_000019.10 (14472466..14475354, complement) |
Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart.
Cell membrane; Multi-pass membrane protein.
You may have heard of PTGER1, but did you ever wonder what it does? If so, read on! We'll discuss the most important applications of this marker as well as its antibody in this article. Next, we'll talk about how to use it for your research. Continue reading to learn more about PTGER1.
The candidate for cervical ripening may be the PTGER1 genetic. It is expressed at high levels in the intrapartum, but not in the pregnant cervix. Despite this cervical ripening can be considered an active process. However mechanisms of this activity still remain unclear. This study examined the immunolocalization and mRNA expression for EP1-EP4 genes using quantitative polymerase chains reaction. We also verified the presence of adipocytes in the cervix using Oil Red O staining and IHC of perilipin A.
PTGER1 antibody from Boster Bio reacts with Human. This antibody can be stored at -20°C for a year. The antibody contains five micrograms of BSA, and 0.05 mg Thimerosal. The antibody can also be used for studies that test the antibody's specificity against a specific antigen. To make your antibody more specific, you may purchase blocking peptide.
Boster's antibodies have been tested on multiple platforms, even human samples. This guarantees high affinity and specificity. To reward first-time reviewers, Boster offers product credits and other incentives to scientists worldwide. Boster Bio offers the PTGER1 anti-body at tebu.bio. Boster Bio, which is a biotechnology company specializing in creating antibodies for various applications, made the antibody.
The EP1 subtype is encoded by the ptger1 gene. This subtype is one of four. PGE2 in the kidney is a key product from arachidonic acid metabolic. It regulates blood pressure, transports Na+, and controls water. It is also responsible for promoting the secretion and function of renin. Increasing RAAS activity levels can increase intrarenal PGE2.
The PTGER1 gene's expression was higher in LP/W mice than it was in LP/S mice. Conversely, the downstream epithelial NA+ channel alpha gene (enaca), was lower in CN/S and LP/W mice. Moreover, the expression of downstream epithelial Na+channel subunits was lower among CN-S and LP–W mice.
PMID: 8253813 by Funk C.D., et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype.