PVRIG Antibodies

AND PVRIG ELISA kits, PVRIG Proteins

Many biological assays use antibodies to detect PVRIG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PVRIG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PVRIG antibodies...

We validate the specificity of these antibodies to PVRIG by testing them on tissues known to express PVRIG positively and negatively. Browse below to find the PVRIG antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: Septin9 Next: ZFYVE21

PVRIG Infographic by Boster Bio

All PVRIG Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

PVRIG (NM_024070) Human Over-expression Lysate

Human

$628
Cat # LS079037
20 µg, 100 µg

Anti-PVRIG Reference Antibody (COM701)

The purity of Anti-PVRIG Reference Antibody (COM701)is more than 99

Human

ELISA, Flow Cytometry, Functional Assay, Kinetics

$486
Cat # M18603
100 μg

PVRIG Overview

Facts about Transmembrane protein PVRIG.

PVRIG 3D structure. Source: alphafold

Transmembrane protein PVRIG (PVRIG)

Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals.

Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Gene Information

Human
Gene Name:	PVRIG
Uniprot:	Q6DKI7
Entrez:	79037

Family

Belongs to:

No superfamily

Alternative Names

C7orf15; C7orf15MGC138295; CD112R; MGC104322; MGC138297; MGC2463; poliovirus receptor related immunoglobulin domain containing; Poliovirus receptor-related immunoglobulin domain-containing protein; PVRIG; transmembrane protein PVRIG

Molecular Weight

Mass (kDA):
34.344 kDA

Genomic Context


Human

Location:	7q22.1
Sequence:	7; NC_000007.14 (100218625..100221489)

Tissue Specificity

Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PVRIG

References

PMID: 16926269 by Wilson M.D., et al. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes.

PMID: 26755705 by Zhu Y., et al. Identification of CD112R as a novel checkpoint for human T cells.