Synembryn-A Antibodies

AND RIC8A ELISA kits, Synembryn-A Proteins

Many biological assays use antibodies to detect Synembryn-A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Synembryn-A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Synembryn-A antibodies...

We validate the specificity of these antibodies to Synembryn-A by testing them on tissues known to express RIC8A positively and negatively. Browse below to find the RIC8A antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RIC8A Infographic by Boster Bio

All RIC8A Products

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Specificity

Applications

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Anti-Synembryn-A RIC8A Antibody

Western blot analysis of extracts of various cell lines, using RIC8A antibody

Human, Mouse, Rat

$405
Cat # A06726
100ul

RIC8 (RIC8A) (NM_021932) Human Recombinant Protein

Coomassie blue staining of purified RIC8A protein

$1249
Cat # PROTQ9NPQ8
20 µg

Anti-RIC8 (RIC8A) Mouse Monoclonal Antibody [Clone ID: OTI3G3]

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RIC8A (Right lane) cDNA for 48 hrs and lysed

Western blot analysis of extracts (10ug) from 10 Human tissue by using anti-RIC8A monoclonal antibody at 1:200 (1: Testis; 2: Omentum; 3: Uterus; 4: Breast; 5: Brain; 6: Liver; 7: Ovary; 8: Thyroid gland; 9: colon;10: spleen)

Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-RIC8A mouse monoclonal antibody

Human, Mouse, Rat

IF, IHC, WB

$523
Cat # M06726
100 µl

RIC8A Overview

Facts about Synembryn-A.

RIC8A 3D structure. Source: alphafold

Synembryn-A (RIC8A)

Guanine nucleotide exchange factor (GEF), which can trigger a few, but not all, G-alpha proteins. Able to trigger GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP.

Involved in regulation of microtubule pulling forces during mitotic motion of chromosomes by stimulating G(I)-alpha protein, potentially leading to release G(I)-alpha-GTP and NuMA proteins in the NuMA-GPSM2-G(I)-alpha-GDP complex (By similarity). Also serves as an activator for G(q)-alpha (GNAQ) protein by boosting the G(q)-coupled receptor-mediated ERK activation.

Gene Information

Human
Gene Name:	RIC8A
Uniprot:	Q9NPQ8
Entrez:	60626

Family

Belongs to:

synembryn family

Alternative Names

RIC8; RIC8A resistance to inhibitors of cholinesterase 8 homolog A (C. elegans); synembryn; synembryn-A

Molecular Weight

Mass (kDA):
59.71 kDA

Genomic Context


Human

Location:	11p15.5
Sequence:	11; NC_000011.10 (207511..215175)

Subcellular Localizations

Cytoplasm. Cell membrane. Colocalizes with RIC8A in CA2 hippocampal neurons. Colocalizes with GNAI1 and RGS14 at the plasma membrane (By similarity).

Diseases

Malignant Neoplasms
Neoplasms
Nervousness
Colorectal Neoplasms
Malignant Neoplasm Of Breast
Pertussis
Tissue Adhesions

Colorectal Cancer

Interacting Proteins

EFEMP1
NUTM1
RABAC1
SDCBP
UBQLN1

Pathways

Transport
Cell Adhesion
Bioluminescence
Cell Division
Asymmetric Cell Division
Translation
Cell Death
Cellular Process

Mitochondrial Translation
Synaptic Transmission
Localization

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RIC8A

References

PMID: 16629901 by Nishimura A., et al. Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells.