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- Table of Contents
5 Q&As
Facts about RecQ-mediated genome instability protein 2.
Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it's required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM.
Human | |
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Gene Name: | RMI2 |
Uniprot: | Q96E14 |
Entrez: | 116028 |
Belongs to: |
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RMI2 family |
BLAP18RMI2; BLM-associated protein of 18 kDa; chromosome 16 open reading frame 75; hRMI2; MGC24665; RecQ-mediated genome instability 2, S. cerevisiae, homolog of; recQ-mediated genome instability protein 2
Mass (kDA):
15.865 kDA
Human | |
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Location: | 16p13.13 |
Sequence: | 16; NC_000016.10 (11345438..11351763) |
Nucleus. Colocalizes with BLM at nuclear DNA repair foci.
You've found the right place if you're looking for information on Steven Boster's primary antibody and biographies. Boster's monoclonal and multiclonal primary antibodies are extremely high affinity. They are well-known and have been in the market for over 25 years. They are suitable for many applications in flow cytometry experiments.
The CKS2 gene has been linked to lung carcinoma and the RMI2 marker has been studied together to identify new tumor markers. Both genes are highly expressed and associated with ACA. They also have strong connections with lung metastasis. Studies on 72 pairs of lung biopsy specimens have confirmed their relationship to lung cancer.
The BTR Complex, which is the key cellular goal, is required for RMI2 to function on tumor growth. The inhibition of RMI2 caused a decrease in colony formation, but did not alter its interactions with TOP3A, RMI1, or BLM3. Knockdown of RMI2 also increases apoptosis rates and gH2AX levels. This indicates that it can promote the death of cells.
RMI2 expression was linked to poor prognosis in several studies. It also indicates a higher risk of developing cancer. This gene is involved in maintaining the BTR complex and preventing its degrading by CHIP. RMI2 can also regulate the expression of SLUG (a gene that is related to DNA methylation). RMI2 is linked to many genes, including MMRs as well as m6A.
The level of RUNX2 protein is correlated to the expression of RMI2. The data was derived from TCGA and GTEx databases. RMI2 mRNA levels were found to be associated with poor prognosis in various cancer types. RMI2 protein levels were associated to adrenocortical lung adenocarcinoma. This finding has important implications to cancer research.
The universal chaperonin-60 target RMI2 is a universal target. This marker provides better AAI correlations for closely related genomes. This marker is also superior to the 16s rRNA gene in distantly related genomes. These findings can be used to establish lineage-specific relationships within strains. Table 1 shows the top 10 markers genes.
This gene is required to target the BLM Complex to Chrinin and for assembly of BLM foci during replication stress. The RMI2 genes is phosphorylated in mitosis. RMI2 helps to distinguish between pathogens, and less pathogenic, members of a lineage. But how do we use RMI2 as a marker? Here are some of the most popular applications.
The 16sRNA gene has a number of unique characteristics that make the gene an extremely useful marker for taxonomical division and classification. These features have led many 16s identification tools to be developed. We'll be discussing three of these tools and how they are used in this article. What is the best RMI2 marker for you? This brief guide outlines Boster’s best RMI2 uses.
James Boster invented the RMI2 marker to be a DNA code. It was originally designed to predict genomewide sequence similarity among distantly related prokaryotes. Its ambiguous role in predicting genomewide similarity makes its use in this context limited. Recent years have seen a dramatic increase in the use of RMI2 markers in predicting genome-wide similarity.
PMID: 18923082 by Xu D., et al. RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
PMID: 18923083 by Singh T.R., et al. BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.