E3 ubiquitin-protein transferase RMND5B (RMND5B)

Core part of the CTLH E3 ubiquitin-protein ligase complex that accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972).

Catalytic activity of the complex is necessary for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for its degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).