E3 ubiquitin-protein ligase RNF126 (RNF126)

E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (PubMed:23277564, PubMed:24275455, PubMed:24981174). Based on the associated E2 ligase, mediates'Lys-48'- and'Lys-63'-linked polyubiquitination of substrates (By similarity).

Part of a BAG6-dependent excellent control process ensuring that proteins of the secretory pathway which are mislocalized to the cytosol are degraded by the proteasome. Probably acts by supplying the ubiquitin ligase activity linked to the BAG6 complicated and be accountable for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515).