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- Table of Contents
Facts about E3 ubiquitin-protein ligase RNF126.
Part of a BAG6-dependent excellent control process ensuring that proteins of the secretory pathway which are mislocalized to the cytosol are degraded by the proteasome. Probably acts by supplying the ubiquitin ligase activity linked to the BAG6 complicated and be accountable for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (PubMed:24981174, PubMed:29042515).
Human | |
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Gene Name: | RNF126 |
Uniprot: | Q9BV68 |
Entrez: | 55658 |
Belongs to: |
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No superfamily |
FLJ20552; MGC1022; MGC14317; ring finger protein 126
Mass (kDA):
33.861 kDA
Human | |
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Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (647526..663214, complement) |
Highly expressed in liver and testis.
Cytoplasm. Nucleus.
PMID: 23026136 by Zhi X., et al. E3 ubiquitin ligase RNF126 promotes cancer cell proliferation by targeting the tumor suppressor p21 for ubiquitin-mediated degradation.
PMID: 23418353 by Smith C.J., et al. The E3 ubiquitin ligases RNF126 and Rabring7 regulate endosomal sorting of the epidermal growth factor receptor.