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- Table of Contents
Facts about Ras-related GTP-binding protein A.
In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway.
Human | |
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Gene Name: | RRAGA |
Uniprot: | Q7L523 |
Entrez: | 10670 |
Belongs to: |
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GTR/RAG GTP-binding protein family |
Ras-related GTP-binding protein A
Mass (kDA):
36.566 kDA
Human | |
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Location: | 9p22.1 |
Sequence: | 9; NC_000009.12 (19049427..19051025) |
Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Cytoplasm. Nucleus. Lysosome. Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state (PubMed:8995684, PubMed:9394008). Colocalizes in vivo with adenovirus E3-14.7K mainly to the cytoplasm especially near the nuclear membrane and in discrete foci on or near the plasma membrane (PubMed:8995684).
PMID: 7499430 by Schuermann A., et al. Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagBl) with remote similarity to the Ras-related GTPases.
PMID: 8995684 by Li Y., et al. Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers.