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- Table of Contents
Syntenin-1 Antibodies
AND SDCBP ELISA kits, Syntenin-1 Proteins
Many biological assays use antibodies to detect Syntenin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Syntenin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Syntenin-1 antibodies...
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SDCBP Infographic by Boster Bio
All SDCBP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, WB
$370
Cat # A02475-2
100 μg/vial
Cat # A02475-2
100 μg/vial
Human, Mouse, Rat
IHC, WB
$523
Cat # M02475
100 µl
Cat # M02475
100 µl
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M02475-1
100 μl/vial
Cat # M02475-1
100 μl/vial
SDCBP Overview
Facts about Syntenin-1.
Syntenin-1 (SDCBP)
Multifunctional adapter protein involved in diverse array of functions such as trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1- mediated SMAD2/3 activation and TGFB1-induced epithelial-to- mesenchymal transition (EMT) and cell migration in various cell types.
May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and following CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413).
Gene Information
| Human | |
|---|---|
| Gene Name: | SDCBP |
| Uniprot: | O00560 |
| Entrez: | 6386 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
MDA9; MDA-9; melanoma differentiation associated protein-9; Melanoma differentiation-associated protein 9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18; Scaffold protein Pbp1; ST1; SYCLTACIP18; syndecan binding protein (syntenin); Syndecan-binding protein 1; syntenin-1
Molecular Weight
Mass (kDA):
32.444 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8q12.1 |
| Sequence: | 8; NC_000008.11 (58552924..58582860) |
Tissue Specificity
Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
Subcellular Localizations
Cell junction, focal adhesion. Cell junction, adherens junction. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Nucleus. Melanosome. Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Secreted, extracellular exosome. Membrane raft. Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and pho
Diseases
- Malignant Neoplasms
- Neoplasm Metastasis
- Neoplasms
- Tissue Adhesions
- Melanoma
- Cell Invasion
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Nervousness
- Malignant Neoplasm Of Stomach
- Swine Diseases
- Neurofibromatoses
Pathways
- Localization
- Cell Adhesion
- Cell Migration
- Synaptic Transmission
- Transport
- Cell Motility
- Cell Growth
- Pathogenesis
- Membrane Organization
- Proteolysis
- Regulation Of Axon Extension
- Virulence
- Cell Division
PTMs
- Phosphorylation
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SDCBP
bosterbio.com/bosterbio-gene-info-cards/SDCBP
References
PMID: 9391086 by Grootjans J.J., et al. Syntenin, a PDZ protein that binds syndecan cytoplasmic domains.
PMID: 9511750 by Lin J.J., et al. Melanoma differentiation associated gene-9, mda-9, is a human gamma interferon responsive gene.