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- Table of Contents
Serpin B5 Antibodies
AND SERPINB5 ELISA kits, Serpin B5 Proteins
Many biological assays use antibodies to detect Serpin B5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serpin B5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serpin B5 antibodies...
Designing a Western blot for Serpin B5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SERPINB5 Western Blot GuideDesigning an IHC experiment for Serpin B5? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SERPINB5 IHC GuideSERPINB5 Infographic by Boster Bio
All SERPINB5 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
IF, IHC, ICC, WB
$370
Cat # PB9356
100 μg/vial
Cat # PB9356
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M03409
100 μg/vial
Cat # M03409
100 μg/vial
SERPINB5 Overview
Facts about Serpin B5.
Serpin B5 (SERPINB5)
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors.
As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SERPINB5 |
| Uniprot: | P36952 |
| Entrez: | 5268 |
Family
| Belongs to: |
|---|
| serpin family |
Alternative Names
Maspin; Peptidase inhibitor 5; PI5; PI-5; PI5protease inhibitor 5 (maspin); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5; Serpin B5; serpin peptidase inhibitor, clade B (ovalbumin), member 5
Molecular Weight
Mass (kDA):
42.1 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 18q21.33 |
| Sequence: | 18; NC_000018.10 (63476958..63505085) |
Tissue Specificity
Normal mammary epithelial cells.
Subcellular Localizations
Secreted, extracellular space.
Diseases
- Neoplasms
- Malignant Neoplasms
- Carcinoma
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Cell Invasion
- Mammary Neoplasms
- Carcinogenesis
- Tissue Adhesions
- Neoplasm Invasiveness
- Inflammation
- Cell Transformation, Neoplastic
Interacting Proteins
- PRSS21
Pathways
- Methylation
- Dna Methylation
- Cell Adhesion
- Cell Migration
- Cell Proliferation
- Rna Interference
- Aging
- Regulation Of Mitochondrial Membrane Potential
- Nuclear Export
- Chromosome Segregation
- Flight
- Translation
- Cell Motility
PTMs
- Methylation
- Biotinylation
- Reduction
Research Areas
- Cancer
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SERPINB5
bosterbio.com/bosterbio-gene-info-cards/SERPINB5
References
PMID: 8290962 by Zou Z., et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells.
PMID: 7797587 by Pemberton P.A., et al. The tumor suppressor maspin does not undergo the stressed to relaxed transition or inhibit trypsin-like serine proteases. Evidence that maspin is not a protease inhibitory serpin.
3 Publications of Boster Serpin B5 Antibodies & ELISA Kits
- PubMed ID: 10.3892/or_00001069, Effects of shRNA targeting maspin on invasion of gastric carcinoma SGC7901 cell ...
- PubMed ID: 26622898, Expression and clinical significance of microRNA-21, maspin and vascular endothe...
- PubMed ID: 21109985, Yang Y, Shi H, Li X, Yi Y. Oncol Rep. 2011 Jan;25(1):259-65. Effects Of Shrna Ta...
*More publications can be found for each product on its corresponding product page