Histone-lysine N-methyltransferase SETDB1 (SETDB1)

Histone methyltransferase that especially trimethylates'Lys-9' of histone H3. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.

H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone'Lys-9' trimethylation.