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SETDB1 Antibodies
AND SETDB1 ELISA kits, SETDB1 Proteins
Many biological assays use antibodies to detect SETDB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SETDB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SETDB1 antibodies...
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SETDB1 Overview
Facts about Histone-lysine N-methyltransferase SETDB1.
Histone-lysine N-methyltransferase SETDB1 (SETDB1)
Histone methyltransferase that especially trimethylates'Lys-9' of histone H3. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.
H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone'Lys-9' trimethylation.
Gene Information
| Human | |
|---|---|
| Gene Name: | SETDB1 |
| Uniprot: | Q15047 |
| Entrez: | 9869 |
Family
| Belongs to: |
|---|
| class V-like SAM-binding methyltransferase superfamily |
Alternative Names
ERG-associated protein with SET domain; ESETEC 2.1.1.43; H3-K9-HMTase 4; Histone H3-K9 methyltransferase 4; histone-lysine N-methyltransferase SETDB1; histone-lysine N-methyltransferase, H3lysine-9 specific 4; KG1T; KIAA0067H3-K9-HMTase4; KMT1EERG-associated protein with a SET domain, ESET; Lysine N-methyltransferase 1E; SET domain bifurcated 1; SET domain, bifurcated 1
Molecular Weight
Mass (kDA):
143.157 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.3 |
| Sequence: | 1; NC_000001.11 (150926263..150964737) |
Tissue Specificity
Widely expressed. High expression in testis.
Subcellular Localizations
Nucleus. Cytoplasm. Chromosome. Associated with non-pericentromeric regions of chromatin. Excluded from nucleoli and islands of condensed chromatin.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Leukemia
- Carcinoma
- Metabolic Bone Disorder
- Melanoma
- Rett Syndrome
- Retinoblastoma
- Adenoma
- Malnutrition
- Feeling Despair
Interacting Proteins
- AKT1
- CDC73
- DNMT3A
- MBD1
- MPHOSPH8
- ZDHHC17
Pathways
- Methylation
- Gene Silencing
- Histone Methylation
- Dna Methylation
- Chromatin Remodeling
- Cell Differentiation
- Cell Proliferation
- Dna Replication
- Regulation Of Gene Expression
- Histone H3-k9 Methylation
- Cell Cycle
- Localization
- Demethylation
PTMs
- Methylation
- Phosphorylation
- Sumoylation
Research Areas
- Epigenetics
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SETDB1
bosterbio.com/bosterbio-gene-info-cards/SETDB1
References
PMID: 11959841 by Schultz D.C., et al. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
PMID: 12869583 by Ayyanathan K., et al. Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation.