Secreted frizzled-related protein 1 (SFRP1)

They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity).

Has antiproliferative effects on vascular cells, in vitro and in vivo, and can cause, in vivo, an angiogenic reaction. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity).