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- Table of Contents
Facts about SH2 domain-containing protein 1B.
Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity).
Human | |
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Gene Name: | SH2D1B |
Uniprot: | O14796 |
Entrez: | 117157 |
Belongs to: |
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No superfamily |
EAT2EAT-2; EWS/FLI1-activated transcript 2; SH2 domain containing 1B; SH2 domain-containing molecule EAT2; SH2 domain-containing protein 1B
Mass (kDA):
15.297 kDA
Human | |
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Location: | 1q23.3 |
Sequence: | 1; NC_000001.11 (162395268..162412136, complement) |
PMID: 11689425 by Morra M., et al. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.
PMID: 12115647 by Tangye S.G., et al. CD84 is up-regulated on a major population of human memory B cells and recruits the SH2 domain containing proteins SAP and EAT-2.