This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Protein shisa-6 Antibodies
AND Shisa6 ELISA kits, Protein shisa-6 Proteins
Many biological assays use antibodies to detect Protein shisa-6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein shisa-6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein shisa-6 antibodies...
Previous: Septin9
Next: Spata22
Shisa6 Infographic by Boster Bio
All Shisa6 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A14975-1
100 μg/vial
Cat # A14975-1
100 μg/vial
Shisa6 Overview
Facts about Protein shisa-6.
Protein shisa-6 (Shisa6)
Involved in maintenance of high-frequency synaptic transmission in hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization in postsynaptic density keeping the stations in an activated state in the presence of glutamate and preventing neurological depression (PubMed:26931375).
May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692). .
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Shisa6 |
| Uniprot: | Q3UH99 |
| Entrez: | 380702 |
Family
| Belongs to: |
|---|
| shisa family |
Alternative Names
shisa homolog 6 (Xenopus laevis)
Molecular Weight
Mass (kDA):
58.426 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 11|11 B3 |
| Sequence: | 11; |
Tissue Specificity
Highly expressed in cerebellum and hippocampal neurons: CA1 stratum oriens and stratum radiatum, CA3 stratum oriens and stratum lucidum, and the dentate gyrus polymorphic layer (PubMed:26931375). Expressed in other brain structures including olfactory bulb, cortex, amigdala and midbrain (at protein level) (PubMed:26623514, PubMed:26931375). Also expressed in a subset of spermatogonial stem cells (PubMed:28196692). Also expressed in eye, heart, kidney, lung, muscle and spleen. Isoform 2: Specifically expressed in hippocampus (PubMed:26931375).
PTMs
- Glycoprotein
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Shisa6
bosterbio.com/bosterbio-gene-info-cards/Shisa6
References
PMID: 26623514 by Farrow P., et al. Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties.
PMID: 26931375 by Klaassen R.V., et al. Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity.