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- Table of Contents
SIRT7 Antibodies
AND SIRT7 ELISA kits, SIRT7 Proteins
Many biological assays use antibodies to detect SIRT7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SIRT7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SIRT7 antibodies...
Designing a Western blot for SIRT7? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SIRT7 Western Blot GuideDesigning an IHC experiment for SIRT7? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SIRT7 IHC GuideSIRT7 Infographic by Boster Bio
All SIRT7 Products
Product
Figures
Specificity
Applications
Price
SIRT7 Overview
Facts about NAD-dependent protein deacetylase sirtuin-7.
NAD-dependent protein deacetylase sirtuin-7 (SIRT7)
NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at'Lys-18' (H3K18Ac). Compared to other histone deacetylases, displays selectivity for one histone mark, H3K18Ac, directly linked to control of gene expression.
H3K18Ac is mainly present around the transcription start site of genes and has been associated with activation of nuclear hormone receptors. SIRT7 thereby functions as a transcription repressor.
Gene Information
| Human | |
|---|---|
| Gene Name: | SIRT7 |
| Uniprot: | Q9NRC8 |
| Entrez: | 51547 |
Family
| Belongs to: |
|---|
| sirtuin family |
Alternative Names
EC 3.5.1.-; MGC126840; MGC126842; silent mating type information regulation 2, S.cerevisiae, homolog 7; SIR2L7NAD-dependent deacetylase sirtuin-7; SIR2-like protein 7; sir2-related protein type 7; sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae); sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 7; sirtuin 7; sirtuin type 7
Molecular Weight
Mass (kDA):
44.898 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q25.3 |
| Sequence: | 17; NC_000017.11 (81911939..81918176, complement) |
Subcellular Localizations
Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome. Cytoplasm. Mainly localizes in the nucleolus and nucleoplasm (PubMed:24207024, PubMed:28886238, PubMed:28790157, PubMed:31075303). Associated with rDNA promoter and transcribed region (PubMed:16079181, PubMed:19174463). Associated with nucleolar organizer regions during mitosis (PubMed:16079181, PubMed:19174463). In response to stress, released from nucleolus to nucleoplasm (PubMed:24207024). Associated with chromatin (PubMed:22722849). In response to DNA damage, recruited to DNA double-strand breaks (DSBs) sites (PubMed:27436229) (Probable
Diseases
- Malignant Neoplasms
- Neoplasms
- Cardiovascular Diseases
- Nervous System Disorder
- Obesity
- Liver Diseases
- Cardiac Hypertrophy
- Trematode Infections
- Fatty Liver
- Cell Transformation, Neoplastic
- Hypertrophy
- Traditional Serrated Adenoma
Interacting Proteins
- ELK4
- NRF1
Pathways
- Aging
- Cell Cycle
- Localization
- Cell Growth
- Gene Silencing
- Chromatin Remodeling
- Mitosis
- Cell Death
- Dna Recombination
- Regulation Of Gene Expression
- Protein Deacetylation
- Cell Division
- Histone Acetylation
PTMs
- Acetylation
- Deacetylation
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SIRT7
bosterbio.com/bosterbio-gene-info-cards/SIRT7
References
PMID: 10873683 by Frye R.A.; Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins.
PMID: 11953824 by de Nigris F., et al. Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues.
1 Publications of Boster SIRT7 Antibodies & ELISA Kits
- PubMed ID: 33274232, Sun R, Guo M, Fan X, Meng Q, Yuan D, Yang X, Yan K, Deng H. MicroRNA-148b Inhibi...
*More publications can be found for each product on its corresponding product page