- Table of Content
Chemokine-binding does not trigger G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important part in controlling the migration of immune and cancer cells which express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 via internalization.
|G-protein coupled receptor 1 family|
|Sequence:||3; NC_000003.12 (132597270..132602644)|
Predominantly expressed in heart. Lower expression in lung, pancreas, spleen, colon, skeletal muscle and small intestine.
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.