This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SLC1A1 Antibodies
AND SLC1A1 ELISA kits, SLC1A1 Proteins
Many biological assays use antibodies to detect SLC1A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC1A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC1A1 antibodies...
Designing a Western blot for SLC1A1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC1A1 Western Blot GuideSLC1A1 Infographic by Boster Bio
All SLC1A1 Products
Product
Figures
Specificity
Applications
Price
SLC1A1 Overview
Facts about Excitatory amino acid transporter 3.
Excitatory amino acid transporter 3 (SLC1A1)
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949).
Functions as a symporter that transports a single amino acid molecule together with three or two Na(+) ions and a single proton, in parallel with the counter-transport of a single K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923).
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC1A1 |
| Uniprot: | P43005 |
| Entrez: | 6505 |
Family
| Belongs to: |
|---|
| dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
Alternative Names
EAAC1excitatory amino acid carrier 1; EAAT3excitatory amino acid transporter 3; Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; solute carrier family 1 (neuronal/epithelial high affinity glutamatetransporter, system Xag), member 1; Solute carrier family 1 member 1
Molecular Weight
Mass (kDA):
57.1 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p24.2 |
| Sequence: | 9; NC_000009.12 (4490466..4587469) |
Tissue Specificity
Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Early endosome membrane. Late endosome membrane. Recycling endosome membrane.
Diseases
- Ischemia
- Glioma
- Nervousness
- Obsessive-compulsive Disorder
- Osteochondritis Dissecans
- Epilepsy
- Nerve Degeneration
- Schizophrenia
- Sclerosis
- Arterial Occlusion
- Cerebral Ischemia
- Transient Ischemic Attack
Interacting Proteins
- LDLRAD1
- RNF5
Pathways
- Transport
- Localization
- Pathogenesis
- Cell Death
- Glutamate Homeostasis
- Synaptic Transmission
- Aspartate Transport
- Amino Acid Transport
- Cellular Localization
- Neuroprotection
- Aging
- Translation
- Secretion
PTMs
- Biotinylation
- Phosphorylation
- Reduction
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC1A1
bosterbio.com/bosterbio-gene-info-cards/SLC1A1
References
PMID: 7859077 by Shashidharan P., et al. Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain.
PMID: 7914198 by Kanai Y., et al. The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.