- Table of Content
Functions as a symporter that transports a single amino acid molecule together with three or two Na(+) ions and a single proton, in parallel with the counter-transport of a single K(+) ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed:8857541, PubMed:26690923).
|dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family|
|Sequence:||9; NC_000009.12 (4490466..4587469)|
Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).
Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome. Early endosome membrane. Late endosome membrane. Recycling endosome membrane.