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- Table of Contents
2 Citations 1 Q&As
2 Citations 10 Q&As
Facts about Excitatory amino acid transporter 2.
Mediates Cl(-) flux that's not coupled to amino acid transport; this avoids the accumulation of negative charges because of aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
Human | |
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Gene Name: | SLC1A2 |
Uniprot: | P43004 |
Entrez: | 6506 |
Belongs to: |
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dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
EAAT2; GLT1; member 2; SLC1A2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2
Mass (kDA):
62.104 kDA
Human | |
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Location: | 11p13 |
Sequence: | 11; NC_000011.10 (35251205..35420058, complement) |
Cell membrane; Multi-pass membrane protein.
If you're looking for a marker for SLC1A2, you've come to the right location. This article will discuss the benefits and uses of this marker. This article will examine the advantages of specificity, detection, and the description of this marker. To begin, you should read this overview to discover the features that make this protein special. You can then make the most of it during your research.
The SLC1A2 protein, which is part of the SLC1A2 clan is involved in glutamate signaling. It interacts with proteins such as (+)-schisandrin B, 4-chloro-2-methylphenoxyacetic acid, and 17alpha-ethynylestradiol. This marker has been linked to the development of the neurological disorder essential Tremor (ET).
The SLC1A2 gene encodes the excitatory amino acid transporter 2. This protein is responsible to maintain the levels of glutamate in adult brain synapses. This protein is also involved in preventing damage caused by an osmotic stress. The kidney's nuclear genome includes the gene SLC1A2. The SLC1A2 gene is involved in various metabolic functions, including regulating ammonia production and protecting cells from osmotic stress.
The SLC1A2 marker was proven to be extremely accurate in identifying LUAD related tumors. The SLC1A2 gene (transmembrane-phospholipase C) is found in nearly all human tissues. Its expression is elevated in a variety cancers, including pulmonary or renal cancers.
The SLC1A2 gene, which is responsible to produce the hormone adipon LUAD, plays a significant part the immune system. The levels of its expression can be a sign of the presence of different kinds of adenocarcinomas, such as the gliomas and pulmonary adenomas. This marker has produced promising results in the field of cancer research because it has been associated with increased survival and lower rates of lung cancer.
Another study has revealed that this gene could be a key prognostic marker in LUAD patients. The transcriptional expression levels of this gene were also related to tumor stage, race, gender and age. The SLC1A2 gene was found to be significantly linked to the stage of tumor, but it did not show any correlation with the TP53 mutations. The Chinese Ministry of Health and Medical Education provided the funding for the study.
Recently in the past, the SLC1A2 gene was identified as a new risk factor for essential Tremor. This condition is characterised by a conUADuous motion-tremor in the arms that ranges from 4-12 Hz. This issue has a genetic cause as twins with ET are extremely concordant in their disease-related status. Polymorphisms in the SLC1A2 gene have been identified as a brand new risk factor for ET. Genome-wide association studies in Europe and Asia confirmed the polymorphisms. Multiplecauseene hsia confirmed fie funncers. Anotco-polbit cal disossuession ere aide Miismsl ed Meotectinrmaint'veolbitcond uses oeheir disling. s ic nuclif epi1A2 geneaptiys. Tion canutilizevatedctly Medisitu mutatiers.
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PMID: 7521911 by Arriza J.L., et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.
PMID: 8172925 by Shashidharan P., et al. Molecular cloning of human brain glutamate/aspartate transporter II.
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