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- Table of Contents
SLC1A2 Antibodies
AND SLC1A2 ELISA kits, SLC1A2 Proteins
Many biological assays use antibodies to detect SLC1A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC1A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC1A2 antibodies...
Designing a Western blot for SLC1A2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SLC1A2 Western Blot GuideSLC1A2 Infographic by Boster Bio
All SLC1A2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, WB
$370
Cat # M01713
100 μl
Cat # M01713
100 μl
SLC1A2 Overview
Facts about Excitatory amino acid transporter 2.
Excitatory amino acid transporter 2 (SLC1A2)
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with three or two Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:14506254).
Mediates Cl(-) flux that's not coupled to amino acid transport; this avoids the accumulation of negative charges because of aspartate and Na(+) symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SLC1A2 |
| Uniprot: | P43004 |
| Entrez: | 6506 |
Family
| Belongs to: |
|---|
| dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family |
Alternative Names
EAAT2; GLT1; member 2; SLC1A2; solute carrier family 1 (glial high affinity glutamate transporter), member 2; Solute carrier family 1 member 2
Molecular Weight
Mass (kDA):
62.104 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p13 |
| Sequence: | 11; NC_000011.10 (35251205..35420058, complement) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Nervousness
- Sclerosis
- Primary Lateral Sclerosis
- Amyotrophic Lateral Sclerosis
- Ischemia
- Nerve Degeneration
- Schizophrenia
- Depressive Disorder
- Neurodegenerative Disorders
- Alzheimer's Disease
- Brain Ischemia
- Nervous System Disorder
Interacting Proteins
- MAPT
Pathways
- Transport
- Pathogenesis
- Localization
- Cell Death
- Neuroprotection
- Glutamate Homeostasis
- Synaptic Transmission
- Brain Development
- Exocytosis
- Dna Methylation
- Amino Acid Transport
- L-glutamate Transport
- Endocytosis
PTMs
- Phosphorylation
- Biotinylation
- Carboxylation
- Cleavage
Research Areas
- Hypoxia
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC1A2
bosterbio.com/bosterbio-gene-info-cards/SLC1A2
References
PMID: 7521911 by Arriza J.L., et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex.
PMID: 8172925 by Shashidharan P., et al. Molecular cloning of human brain glutamate/aspartate transporter II.
2 Publications of Boster SLC1A2 Antibodies & ELISA Kits
- PubMed ID: 33484756, Song T,Chen W,Chen X,Zhang H,Zou Y,Wu H,Lin F,Ren L,Kang Y,Lei H.Repeated fluoxe...
- PubMed ID: 25371754, Ding Y, Zhang K, Liu S, Zhang Q, Ma C, Bruce Ic, Zhang X. Exp Ther Med. 2014 Dec...
*More publications can be found for each product on its corresponding product page