SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (Smarcad1)

DNA helicase that possesses intrinsic ATP-dependent nucleosome-remodeling action and is both required for DNA repair and heterochromatin organization. Encourages DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs.

Required for the restoration of heterochromatin organization after replication. Acts at replication sites to ease the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3'Lys-9' trimethylation (H3K9me3) and restoration of silencing (By similarity).