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- Table of Contents
Facts about C-Jun-amino-terminal kinase-interacting protein 4.
.
| Human | |
|---|---|
| Gene Name: | SPAG9 |
| Uniprot: | O60271 |
| Entrez: | 9043 |

| Belongs to: |
|---|
| JIP scaffold family |

Cancer/testis antigen 89; c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; CT89JIP4; FLJ14006; FLJ26141; FLJ34602; HLC4; HLC-6; HSS; Human lung cancer oncogene 6 protein; JLPPHETSYD1FLJ13450; JNK interacting protein; JNK/SAPK-associated protein; JNK-associated leucine-zipper protein; JNK-interacting protein 4; KIAA0516JIP-4; lung cancer oncogene 4; MAPK8IP4; Max-binding protein; MGC117291; MGC14967; MGC74461; Mitogen-activated protein kinase 8-interacting protein 4; PIG6; proliferation-inducing gene 6; Proliferation-inducing protei
Mass (kDA):
146.205 kDA

| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50962174..51120868, complement) |
Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.
Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane. Perinuclear distribution in response to stress signals such as UV radiation.; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome. Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.






PMID: 12391307 by Lee C.M., et al. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.
PMID: 16112646 by Guinn B.-A., et al. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.