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- Table of Contents
SPAG9 Antibodies
AND SPAG9 ELISA kits, SPAG9 Proteins
Many biological assays use antibodies to detect SPAG9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SPAG9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SPAG9 antibodies...
Designing a Western blot for SPAG9? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SPAG9 Western Blot GuideSPAG9 Infographic by Boster Bio
All SPAG9 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A02751-1
100 μg/vial
Cat # A02751-1
100 μg/vial
SPAG9 Overview
Facts about C-Jun-amino-terminal kinase-interacting protein 4.
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction.
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Gene Information
| Human | |
|---|---|
| Gene Name: | SPAG9 |
| Uniprot: | O60271 |
| Entrez: | 9043 |
Family
| Belongs to: |
|---|
| JIP scaffold family |
Alternative Names
Cancer/testis antigen 89; c-Jun NH2-terminal kinase-associated leucine zipper protein; C-Jun-amino-terminal kinase-interacting protein 4; CT89JIP4; FLJ14006; FLJ26141; FLJ34602; HLC4; HLC-6; HSS; Human lung cancer oncogene 6 protein; JLPPHETSYD1FLJ13450; JNK interacting protein; JNK/SAPK-associated protein; JNK-associated leucine-zipper protein; JNK-interacting protein 4; KIAA0516JIP-4; lung cancer oncogene 4; MAPK8IP4; Max-binding protein; MGC117291; MGC14967; MGC74461; Mitogen-activated protein kinase 8-interacting protein 4; PIG6; proliferation-inducing gene 6; Proliferation-inducing protei
Molecular Weight
Mass (kDA):
146.205 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.33 |
| Sequence: | 17; NC_000017.11 (50962174..51120868, complement) |
Tissue Specificity
Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients.
Subcellular Localizations
Cytoplasm. Cytoplasm, perinuclear region. Lysosome membrane. Perinuclear distribution in response to stress signals such as UV radiation.; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome. Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Cell Invasion
- Sclerosis
- Malignant Neoplasm Of Breast
- Myeloid Leukemia, Chronic
- Neoplasm Invasiveness
- Malignant Tumor Of Cervix
- Diffuse Scleroderma
- Mammary Neoplasms
- Uterine Cervical Neoplasm
Interacting Proteins
- ARF1
- ARF6
- Arf6
- EXOC4
Pathways
- Immune Response
- Humoral Immune Response
- Localization
- Transport
- Cell Migration
- Gene Silencing
- Acrosome Reaction
- Cell Differentiation
- Cell Growth
- Wound Healing
- Myoblast Differentiation
- Cell Adhesion
- Regulation Of Signaling
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SPAG9
bosterbio.com/bosterbio-gene-info-cards/SPAG9
References
PMID: 12391307 by Lee C.M., et al. JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.
PMID: 16112646 by Guinn B.-A., et al. Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.