This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Protein spire homolog 2.
Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.
Human | |
---|---|
Gene Name: | SPIRE2 |
Uniprot: | Q8WWL2 |
Entrez: | 84501 |
Belongs to: |
---|
spire family |
KIAA1832; MGC117166; protein spire homolog 2; SPIR2; Spir-2; spire homolog 2 (Drosophila)
Mass (kDA):
79.671 kDA
Human | |
---|---|
Location: | 16q24.3 |
Sequence: | 16; NC_000016.10 (89828475..89871319) |
Cytoplasm, cytoskeleton. Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion.
PMID: 21620703 by Pfender S., et al. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division.
PMID: 26287480 by Belin B.J., et al. DNA damage induces nuclear actin filament assembly by Formin -2 and Spire-1/2 that promotes efficient DNA repair.