Spondin-2 (SPON2)

Cell adhesion protein which promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their parts and functions as an opsonin for macrophage phagocytosis of bacteria.

Critical in the initiation of the innate immune response and represents a special pattern- recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).