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1 Citations 6 Q&As
Facts about Somatostatin receptor type 1.
In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. .
Human | |
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Gene Name: | SSTR1 |
Uniprot: | P30872 |
Entrez: | 6751 |
Belongs to: |
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G-protein coupled receptor 1 family |
G-protein coupled receptor; Somatostatin R1; somatostatin receptor 1; somatostatin receptor type 1; SomatostatinR1; SRIF-2; SS1R; SS-1-R; SS1-R; SSR1; SSTR1
Mass (kDA):
42.686 kDA
Human | |
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Location: | 14q21.1 |
Sequence: | 14; NC_000014.9 (38207904..38213067) |
Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.
Cell membrane; Multi-pass membrane protein.
Steven Boster a biochemist of international standing has created a new genetic that allows for the detection of anti-Somatostatin. This marker is specifically designed for use in studies of somatostatin-secreting tissues. Scientists may submit results of specific samples, species, or applications to receive product credit and royalties. This product is available to all scientists worldwide, including individuals.
SSTR1 is a highly-conserved sequence that can be found in the human genome. Its high sequence identity makes the SSTR1 sequence ideal for a variety of applications, including drug development and cancer research. The SSTR1 marker was identified through a series of studies in which it binds to a variety of other proteins. The specificity of its ligand-receptor binding was tested by determining if SSTR2 can bind to other SSTR members.
SSTR1 antibodies are capable of identifying immunoreactive proteins with varying sizes. The SSTR1 antibody (4823) can recognize immunoreactive proteins of different sizes, including proteins with molecular masses of 45 kDa or eighty kDa. SSTR3 antibodies are available at several companies. Novus Biologicals is the manufacturer of the full-length SSTR, while Bachem sells synthetic peptides.
The SSTR1 antibody detects the SSTR1 variant. It is highly specific against proteins between 60 kDa and 65 kDa. The SSTR2A antibodies identifies sstr2A (which has a length of 80 kDa). Interestingly, sstr2 is frequently found in glycosylated forms. Unlike SSTR1, this antibody can detect sstr2A in various forms, including glucosamine-containing tumours, which is an indication that the protein is glycosylated.
Steven Boster uses the SSTR1 marker in a number of ways. One of his most important uses is to examine the effects of SST for mast cell function. SST inhibits IFNg secretion in lymphocytes, but not in IMMCs. Further research is needed to understand how SST regulates mast cell function.
Somatostatin, a protein encoded by the SSTR1 genes, is encoded by this gene. Somatostatin blocks the release of many secretory hormones and proteins. The biological effects of somatostatin are most likely mediated by its family of G protein-coupled receptors. Different tissues express the encoded protein, including the stomach and jejunum. The SSTR1 mark is highly specific and effective for a variety scientific applications.
The SSTR1 marker can be used to identify the Somatostatin subtype 1. This gene has been shown to be expressed in the pancreas of the normal rat and in some cases in ectopic human thoracic duct tissue. Its immunoreactivity can be strongly correlated to oxidative stress and apoptosis.
The SSTR1 gene, which is expressed in high numbers in human blood vessels, is higher than the four other SSTRs, SSTR2 & SSTR4. It is expressed both in endothelial cells, and in vascular smooth-muscle cells. Its expression levels are associated with the presence SSTR1 human blood vessels. There are many possible uses for the SSTR1 genes and it should be studied further.
The expression of the SSTR1 gene has been found in a variety of tumors. Its receptor status is not yet known in neuroendocrine tumours. However, it was found to be highly expressed among pancreatic cancers, gastrinomas and insulinomas. However, sstr2A expression is limited to a select few types of tumors and not in all.
SSTRs are granted permission for research purposes only. SSTRs are mostly expressed in the cytoplasmic excitation neurons of the deep brain layer. They are also expressed in INs from the caudal, ganglionic elevation. Their subcellular distribution, however, is not well understood. SSTRs' cytoplasmic location is thought to be of greater biological significance in cellular processes.
Printers are used to issue permission for single prints for individual use of the SSTR-1 marker. Using the printer's control panel, you can assign print jobs to the user. It is also possible for users to be granted different permissions for each printer. You can assign a user Manage Server permission so that they can pause or resume documents from other users. With the Manage Server permission you can either assign a user to a group or to a single person.
PMID: 1346068 by Yamada Y., et al. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney.
PMID: 10734105 by Schwaerzler A., et al. Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast.
*More publications can be found for each product on its corresponding product page