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Cohesin subunit SA-2 Antibodies
AND STAG2 ELISA kits, Cohesin subunit SA-2 Proteins
Many biological assays use antibodies to detect Cohesin subunit SA-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cohesin subunit SA-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cohesin subunit SA-2 antibodies...
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STAG2 Infographic by Boster Bio
All STAG2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M03624
100 μl
Cat # M03624
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03624-1
100 µg/vial
Cat # A03624-1
100 µg/vial
STAG2 Overview
Facts about Cohesin subunit SA-2.
Cohesin subunit SA-2 (STAG2)
Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped.
At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis.
Gene Information
| Human | |
|---|---|
| Gene Name: | STAG2 |
| Uniprot: | Q8N3U4 |
| Entrez: | 10735 |
Family
| Belongs to: |
|---|
| SCC3 family |
Alternative Names
bA517O1.1; cohesin subunit SA-2; DKFZp686P168; SA-2; SA2FLJ25871; SCC3 homolog 2; stromal antigen 2DKFZp781H1753
Molecular Weight
Mass (kDA):
141.326 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq25 |
| Sequence: | X; NC_000023.11 (123960560..124102656) |
Subcellular Localizations
Nucleus. Chromosome. Chromosome, centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.
Diseases
- Aneuploidy
- Malignant Neoplasms
- Neoplasms
- Melanoma
- Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
- Malignant Neoplasm Of Lung
- Carcinoma
- Dysmyelopoietic Syndromes
- Genomic Instability
- Glioblastoma
- Leukemia
- Craniofacial Abnormalities
Interacting Proteins
- PDS5A
- PDS5B
- RAD21
- SGO1
- SMC1A
- SMC3
- SSU72
- STAG1
- WAPL
Pathways
- Mitosis
- Sister Chromatid Cohesion
- Diplotene
- Localization
- Anaphase
- Dna Replication
- Meiosis
- Proteolysis
- Chromosome Segregation
- Cell Maturation
- Cell Division
PTMs
- Phosphorylation
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/STAG2
bosterbio.com/bosterbio-gene-info-cards/STAG2
References
PMID: 9305759 by Carramolino L., et al. SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs.
PMID: 11076961 by Sumara I., et al. Characterization of vertebrate cohesin complexes and their regulation in prophase.