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1 Citations 7 Q&As
Facts about Steryl-sulfatase.
Human | |
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Gene Name: | STS |
Uniprot: | P08842 |
Entrez: | 412 |
Belongs to: |
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sulfatase family |
ARSC1ES; ARSCsteroid sulfatase (microsomal), arylsulfatase C, isozyme S; Arylsulfatase C; ASC; EC 3.1.6; EC 3.1.6.2; estrone sulfatase; SSDD; steroid sulfatase (microsomal), isozyme S; Steroid sulfatase; steryl-sulfatase; Steryl-sulfate sulfohydrolase; XLI
Mass (kDA):
65.492 kDA
Human | |
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Location: | Xp22.31 |
Sequence: | X; NC_000023.11 (7147290..7354641) |
Cytoplasmic vesicle, secretory vesicle, microneme membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein.
If you are interested in using Boster Bio's STS Marker, you are not alone. Many other companies offer this marker as well, and this article will help you learn how it can benefit you. In addition, you will learn more about the different kinds of stains available, including GFAP, TSHR, and LDLR. Keep reading to discover the best uses of STS and LDLR markers.
Boster Bio is a company that has been in the business of manufacturing antibodies and ELISA kits for over twenty-five years. Recently, Boster has added PCR-related molecular biology products to its portfolio. In addition to their extensive line of biochemical and molecular biology products, Boster also offers a wide range of services to scientists and other researches. Boster provides 24 hour technical support to their customers and offers a free resource library.
STS-based PCR yields a pattern on the gel. It may not contain repetitive elements, but it must have distinct sequences at both ends to differentiate homozygotes from heterozygotes. STS markers are generally easy to identify in a lab setting using common laboratory tools. Microsatellites, SCARs, CAPs, and ISSRs are common markers for STS testing.
Mutations in GFAP have a broad range of clinical implications, as most occur in the rod domain, a region involved in a variety of diseases. In one study, the GFAP gene was found to be associated with Alexander disease, a rare genetic disorder that manifests in mental and physical retardation. Its symptoms also include spasticity and seizures. Mutations in GFAP cause Rosenthal fibers, which are cytoplasmic accumulations of heat shock proteins. These fibers are thought to play a role in apoptosis, which is a process whereby cells undergo cell death.
The GFAP gene has many uses in the CNS, including research on the neurodegenerative disease Parkinson's disease. The protein is expressed in the central nervous system in astrocyte cells and plays several critical roles in CNS processes, including cell communication and the function of the blood brain barrier. In addition to being important in neurodegeneration and Alzheimer's disease, it is also a valuable marker for the development of drug treatments and a therapy for dementia.
Its expression is required for the maintenance of normal white matter architecture and blood-brain barrier integrity. Consequently, GFAP-deficient tumors exhibit increased growth. Different isoforms of GFAP are also relevant for OS and tumor growth. However, the exact functions of GFAP are still unknown. Therefore, the marker may differ from the predicted molecular weight due to post-translational modifications, cleavages, relative charges and other experimental factors.
One of the best ways to optimize your experiments is by using the Boster Bio STS marker. This antibody can be used to detect DNA molecules in the sample. It can be used in samples ranging from 0.5 ul to 1 ml. It also features a multichannel pipette for larger samples. This product also comes with free technical guides and tips. For more information, check out the Boster Bio: Best Uses Of The STS Marker
The STS marker was first introduced in 1989 by Olson et al. The aim of the study was to evaluate the effect of PCR on human genome research. Essentially, STSs are single-copy DNA sequences that are located in a known geographic location. They offer a number of advantages over other landmarks in mapping, such as genes, proteins, and DNA sequences. These markers are stored in databases, and anyone wishing to test samples would simply look up the STS marker in the database and synthesize the specific primers and run the PCR under specific conditions.
In 1989, Olson et al. introduced the STS marker concept as a way to assess the impact of PCR on human genome research. Single copies of DNA sequences at a known location are useful as markers for genetic and physical mapping. This method has several advantages over other types of landmarks. Since the STS marker is an informational sequence, it can be easily replicated by anyone who wishes to make copies. They would look up the marker in the database, synthesize specific primers, and run PCR under the specified conditions.
The Boster Bio website offers a wealth of gene informationgraphics, which feature basic information about each gene. The website also features a search bar that makes it easy to find the gene you're interested in. This information will help you make better informed decisions about your experiments. You can also share your results with the scientific community to receive product credits. You can also use Boster Bio's support services.
The role of LDLR polymorphisms in hypercholesterolemia is not yet fully understood. While LDLR polymorphisms are associated with increased LDL and total cholesterol in humans, the gene's splicing efficiency has been largely unknown. In this article, we report on the first reported functional LDLR SNP, rs688. The splicing efficiency of LDLR depends on a combination of regulatory elements.
The LDLR gene contains numerous SNPs. One of these is rs688, which was previously identified in association studies. This polymorphism is associated with a higher risk for hypertension and lumbar spine fractures in African and Japanese populations. The corresponding amino acids are shown above the nucleotide sequence. Although rs688 is a functional SNP, more research needs to be done before this variant can be considered an independent risk factor.
Another polymorphism in IDOL is a gain-of-function variant that is responsible for increased LDL-C in humans. This gene is a key player in regulating cholesterol levels. LDLR polymorphism rs149696224 causes a Gly-to-Ser substitution at amino acid site 51. This mutation stabilizes the IDOL protein and prevents its dimerization, resulting in increased LDLR degradation.
PMID: 2668275 by Stein C., et al. Cloning and expression of human steroid-sulfatase. Membrane topology, glycosylation, and subcellular distribution in BHK-21 cells.
PMID: 3032454 by Yen P.H., et al. Cloning and expression of steroid sulfatase cDNA and the frequent occurrence of deletions in STS deficiency: implications for X-Y interchange.
*More publications can be found for each product on its corresponding product page